| 口服降糖药曲格列酮的核磁共振谱学表征 |
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| 引用本文： | 尹建元,王恩思.口服降糖药曲格列酮的核磁共振谱学表征[J].吉林大学学报(理学版),2002,40(4):423-425. |
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| 作者姓名： | 尹建元 王恩思 |
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| 作者单位： | 1.吉林大学药学院,长春,130021; 2.吉林大学生命科学学院,长春,130023 |
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| 摘 要： | 利用NMR,IR,UV及MS等实验技术研究了胰岛素增敏剂曲格列酮的波谱学特征.结合DEPT谱及1H-1H COSY 13C-1H HETCOSY,13C-1H LC-HETCOSY对曲格列酮的氢谱和碳谱进行完全归属.
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| 关 键 词： | 抗糖尿病药物 曲格列酮 核磁共振 |
| 文章编号： | 1671-5489(2002)04-0423-03 |
| 收稿时间： | 2002-05-28 |
| 修稿时间： | 2002年5月28日 |
Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone |
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| YIN Jian-yuan,WANG En-si.Nuclear Magnetic Resonance Characterization of Oral Hypoglycemic Drug Troglitazone[J].Journal of Jilin University: Sci Ed,2002,40(4):423-425. |
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| Authors: | YIN Jian-yuan WANG En-si |
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| Institution: | 1. College of Pharmacy , Jilin University , Changchun 130021 , China ;2. College of Life Science , Jilin University , Changchun 130023 , China |
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| Abstract: | The NMR spectra are reported for troglitazone (5-4-(6-hydroxy-2 ,5 ,7 ,8-tetramethyl-3 ,4-dihydrobenzopyran-2-yl-) methoxy ] pheny1 ] methy1] 2,4-thiazolidinedione) that is used as an oral hypoglycemic drug. By using DEPT , 1H-1H COSY , 13C-1H HETCOSY and 13C-1H LC-HETCOSY techniques along with IR , UV and MS , the proton and 13C spectra of troglitazone are assigned completely. This result also provides a basis analysis for the NMR characterization of the similar new drugs. |
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| Keywords: | hypoglycemic drug troglitazone nuclear magnetic resonance |
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