氨丙基修饰M41作为胰岛素的缓释载体

通过水热法合成介孔材料M41,并用3-氨丙基三乙氧基硅烷对其进行修饰.将M41和氨丙基修饰M41作为降糖药物胰岛素的载体,获得药物组装体M41-Ins(M/Ins)和氨丙基修饰M41-Ins(AM/Ins).采用Fourier变换红外光谱(FT-IR)、透射电子显微镜(TEM)、粉末X射线衍射(XRD)、扫描电子显微镜(SEM)和77K低温氮气吸附-解吸附技术对样品进行表征,并监测胰岛素在人工模拟体液中的释放行为,测定其释放率.实验结果表明:M41经氨丙基修饰后仍保持典型的六方孔道结构;经修饰后的M41释药更缓慢.

Aminopropyl Modified M41 as the Sustained Release Carrier of Insulin

M41 was synthesized by hydrothermal method and modified by 3-aminopropyl-triethoxysilane. Both M41 and aminopropyl modified M41 were used as the carriers of insulin,which could reduce blood sugar, to obtain assemblies M41\|Ins(M/Ins) and aminopropyl modified M41\|Ins(AM/Ins). The structures of the prepared materials were characterized by Fourier transform infrared spectroscopy (FT\|IR), transmission electron microscopy (TEM), powder X\|ray diffraction (XRD), scanning electron microscopy (SEM) andlow temperature nitrogen adsorption\|desorption technique at 77 K. The release process of prepared drug sinasimulated body fluid solution was studied and the release rate was determined. The experimental results show that aminopropyl modified M41 also had a typical hexagonal pore structure, with the loading capacity of AM/Ins larger and the drug release rate of AM/Ins was slower than those of M/Ins.