| 3,4,5,6-四溴酚磺酞合成及纯化方法的改进 |
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| 引用本文： | 修志明,黄梦媛,胡冰,雷莉妍,王丽萍.3,4,5,6-四溴酚磺酞合成及纯化方法的改进[J].吉林大学学报(理学版),2013,51(5):965-968. |
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| 作者姓名： | 修志明 黄梦媛 胡冰 雷莉妍 王丽萍 |
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| 作者单位： | 吉林大学 生命科学学院, 长春 130012 |
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| 基金项目： | 吉林省自然科学基金(批准号:201015171);吉林省科技发展计划项目(批准号:201205017);吉林省医药产业发展专项基金(批准号:YYZX201150-2) |
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| 摘 要： | 以2-磺基苯甲酸环酐为原料, 溴代后与苯酚反应合成3,4,5,6-四溴酚磺酞粗产品, 并用溶剂抽提和重结晶方法进行纯化. 结果表明, 所得产物的纯度为97.45%, 收率为36.5%.
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| 关 键 词： | 2-磺基苯甲酸环酐 3 4 5 6-四溴酚磺酞 纯化 |
| 收稿时间： | 2012-08-15 |
Method Improvement of Synthyesis and Purification of3,4,5,6-Tetrabromophenolsulfonephthalein |
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| XIU Zhi-ming;HUANG Meng-yuan;HU Bing;LEI Li-yan;WANG Li-ping.Method Improvement of Synthyesis and Purification of3,4,5,6-Tetrabromophenolsulfonephthalein[J].Journal of Jilin University: Sci Ed,2013,51(5):965-968. |
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| Authors: | XIU Zhi-ming;HUANG Meng-yuan;HU Bing;LEI Li-yan;WANG Li-ping |
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| Institution: | College of Life Science, Jilin University, Changchun 130012, China |
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| Abstract: | 3,4,5,6-Tetrabromophenolsulfonephthalein was synthesized by the reaction of 2-sulfobenzoic acid cyclic anhydride suffered from bromination with phenol. The crude product was purified by solvent extraction and recrystallization with a purity of the product of 97.45%and a yield of 36.5%, respectively. |
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| Keywords: | 2-sulfobenzoic acid cyclic anhydride 3 4 5 6-tetrabromophenolsulfonephthalein purification |
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