钙调素拮抗剂对荷瘤小鼠主要器官钙调素（CaM）水平的影响

本文采用磷酸二酯酶（ＰＤＥ）法，测定了小檗胺衍生物ＥＢＢ对荷Ｓ１８０瘤小鼠的主要器官和瘤体ＣａＭ含量的影响。实验结果表明，ＥＢＢ具有使荷瘤后小鼠脑、肺、肝、脾、肾五个主要器官ＣａＭ由不正常趋向正常的能力，而已知抗肿瘤药物丝裂霉素和环磷酰胺单独使用时此种能力较弱，但这两种抗肿瘤药物与ＥＢＢ联合作用时，能使荷瘤鼠诸器官的ＣａＭ水平趋向正常。结果提示，专一性强的ＣａＭ拮抗剂在抑制肿瘤的同时可能还具有维护

EFFECT OF CALMODULIN ANTAGONIST ON CALMODULIN CONTENT IN ORGANS OF TUMOR BEARING MICE

The effect of Calmodulin(CaM) antagonist-EBB on CaM content was measured with PDE assay in major organs and tumor of S180 bearing mice.As compared with normal mice, the experimental results showed the CaM content in five organs (brain, lung, liver, spleen and kidney) was abnormal after tumor bearing. It is EBB other than MMC or CPA that can chage this abnormality, especially soluble CaM content. The CaM content in tumor of therapeutic groups are lower than the control. EBB also can change the abnormality of total protein in organs by MMC, but it can not change the abnormality by CPA.The results suggest that the reason of tumor inhibition by CaM antagonist-EBB may be involved with function that it can counter the CaM content in major organs of S180bearing mice. So it is worthy further to be studied.