| 马钱子碱固体脂质纳米粒包封率的测定 |
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| 引用本文： | 张亮,管庆霞,赵义军,高佳翔,李永吉.马钱子碱固体脂质纳米粒包封率的测定[J].哈尔滨商业大学学报(自然科学版),2014(3):264-265. |
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| 作者姓名： | 张亮 管庆霞 赵义军 高佳翔 李永吉 |
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| 作者单位： | 黑龙江中医药大学药学院,哈尔滨150040 |
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| 基金项目： | 黑龙江省哈尔滨市科技创新人才专项基金项目（青年科技创新人才）（No.20l1RFQXSl02） |
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| 摘 要： | 建立马钱子碱固体脂质纳米粒中药物包封率的测定方法.采用葡聚糖凝胶柱层析法分离马钱子碱固体脂质纳米粒胶体溶液,再用HPLC测定溶液中马钱子碱的质量浓度,计算包封率.该法测定马钱子碱固体脂质纳米粒中马钱子碱的平均包封率为68.13%,RSD值为0.59%.葡聚糖凝胶法简便,准确,可以作为马钱子碱固体脂质纳米粒的包封率测定方法.
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| 关 键 词： | 马钱子碱 固体脂质纳米粒 包封率 葡聚糖凝胶法 |
Determination of entrapment efficiency of brucine solid lipid nanoparticles |
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| ZHANG Liang,GUAN Qing-xia,ZHAO Yi-jun,GAO Jia-xiang,LI Yong-ji.Determination of entrapment efficiency of brucine solid lipid nanoparticles[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2014(3):264-265. |
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| Authors: | ZHANG Liang GUAN Qing-xia ZHAO Yi-jun GAO Jia-xiang LI Yong-ji |
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| Institution: | (School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China) |
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| Abstract: | In order to establish a method for determining the entrapment efficiency of brucine solid lipid nanoparticles Sephadex gel were used to separate free brucine from solid lipid nan -oparticles,the concentration of brucine was determined by HPLC .Determination of the aver-age entrapment efficiency of Sephadex gel was 68.13%, RSD values were 0.59%.This method was convenient , accurate , and can be used to determine the entrapment efficiency of brucine solid lipid nanoparticles . |
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| Keywords: | brucine solid lipid nanoparticles encapsulating efficiency sephadex gel |
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