舒宁可吸收性止血材料理化性能及止血性能研究

目的:本研究利用壳聚糖和胶原蛋白等材料经低温冷冻等工艺合成舒宁止血材料,通过对其理化性能的分析和止血试验测定以确定其止血性能。方法:1)试验分两组,舒宁止血材料组,明胶海绵组。每组对其物理性质进行测量比较。2)对两组的止血性能进行测定比较。同时,把两种止血材料植入动物体内,分别于15天,30天,60天处死动物,取病理观察两种止血材料组体内降解情况。结果:1)舒宁止血材料组吸水率明显优于明胶海绵组(P<0.05=2),舒宁止血材料组止血性能明显优于明胶海绵组(P<0.05)。两组材料在体内均有降解。结论:舒宁止血材料是一种较为理想的止血材料。其止血性能明显优于明胶海绵组。

Researches on the Physicochemical Properties and Hemostatic Effect of Shuning Absorbable Hemostasis Material

Object:This experiment was carried out to determine hemostatic effect of Shuning hemostatic material made from chitosan and collagen by hypothmonic freezing technique.Methods:1)This test included two groups:Shuning group and gelatin sponge group.The measurement of physical properties were carried out respectively.2)Hemostatic effect were measured in two groups,while two kinds materials were put into the bodies of animals.Ob-servation of animals's pathological changes were completed to determine their degradation in the bodies.Results:1)The absorption rate of water in Shuning group is superior to that in gelatin sponge group(P<0.05).2)The hemostatic effect of Shuning group is better than that of gelatin sponge group(P<0.05).Conclusion:Shuning is one kind of ideal hemostatic materials whose hemostatic effect is better than that of gelatin sponge group.