| 仙芦抗癌胶囊抗肿瘤作用及其作用机制研究 |
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| 引用本文： | 高世勇,李文兰,王帅帅,汲晨锋,张宇金.仙芦抗癌胶囊抗肿瘤作用及其作用机制研究[J].哈尔滨商业大学学报(自然科学版),2004,20(5):505-508. |
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| 作者姓名： | 高世勇 李文兰 王帅帅 汲晨锋 张宇金 |
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| 作者单位： | 哈尔滨商业大学,药物研究所博士后科研工作站,黑龙江,哈尔滨,150076 |
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| 基金项目： | 哈尔滨市科技局攻关项目(2003AA6CN095);黑龙江省青年基金项目(QC02C46). |
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| 摘 要： | 通过观察仙芦抗癌胶囊对S180A和H22荷瘤小鼠瘤重和生存时间的影响,观察其体内抗肿瘤作用.采用荧光探针DPH法,观察仙芦抗癌胶囊对S180A和H22荷瘤小鼠红细胞膜流动性的影响.实验结果发现仙芦抗癌胶囊(1g/kg,0 5g/kg,0 25g/kg)对S180A小鼠的瘤体生长有显著的抑制作用.仙芦抗癌胶囊(1g/kg,0 5g/kg)对H22小鼠的生存时间有显著的延长作用.仙芦抗癌胶囊高、中、低剂量(1g/kg,0 5g/kg,0 25g/kg)均能够升高S180小鼠红细胞膜流动性.仙芦抗癌胶囊高、中剂量(1g/kg,0 5g/kg)均能够降低H22小鼠红细胞膜流动性,而低剂量组无明显作用.因此仙芦抗癌胶囊对S180A和H22都有显著的抑制作用,抗肿瘤作用机制与其恢复荷瘤小鼠红细胞膜流动性有关.
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| 关 键 词： | 仙芦抗癌胶囊 荷瘤小鼠 抗肿瘤作用 膜流动性 作用机制 |
| 文章编号： | 1672-0946(2004)05-0505-04 |
| 修稿时间： | 2004年7月6日 |
Study on anti-tumor function and its mechanism of Xianlu Kang-ai capsule |
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| GAO Shi-Yong,LI Wen-Lan,WANG Shuai-shuai,JI Chen-feng,ZHANG Yu-jin.Study on anti-tumor function and its mechanism of Xianlu Kang-ai capsule[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2004,20(5):505-508. |
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| Authors: | GAO Shi-Yong LI Wen-Lan WANG Shuai-shuai JI Chen-feng ZHANG Yu-jin |
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| Abstract: | The in vivo antitumor action were studied by observing tumor weight and survival time of S_(180) and H_(22) mice. The red cell membrane fluidity of the S_(180) and H_(22) mice was observed by DPH fluorescent probe method. The experiment showed that Xianlu Kang-ai capsule inhibits the growth of cancer cells of S_(180) mice and prolongs the survival time of H_(22) mice. Xianlu Kang-ai capsule could increase the membrance fluidity of the S_(180) and decrease that of the H_(22). So Xianlu Kang-ai capsule shows obvious antitumor effect to S_(180) and H_(22) mice,which is achieve through returning the tumor cell membrance fluidity to the normal one. |
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| Keywords: | Xianlu Kang-ai capsule tumor bearing mice antitumor activity membrance fluidity effect mechanism |
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