| 三环类药物及人参皂甙抗抑郁作用机制的研究 |
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| 引用本文： | 倪小虎,高世勇,史晓丽,安春志,白洁.三环类药物及人参皂甙抗抑郁作用机制的研究[J].哈尔滨商业大学学报(自然科学版),2002,18(1):37-38. |
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| 作者姓名： | 倪小虎 高世勇 史晓丽 安春志 白洁 |
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| 作者单位： | 哈尔滨商业大学制药工程系,黑龙江哈尔滨,150076 |
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| 摘 要： | 本研究采用大鼠强迫游泳实验法考察三环类药物及人参皂甙抗抑郁效果研究,对其脑内单胺类神经递质(去甲肾上腺素、多巴胺、5-羟色胺),用荧光分光光度法进行了定量测定,结果表明:高剂量丙米嗪和人参皂甙能降低脑内游离型去甲肾上腺素、多巴胺、5-羟色胺神经递质,从而使中枢神经系统突触部位结合型递质含量增高.推论三环类药物及人参皂甙抗抑郁作用机制可能与此效应有关.
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| 关 键 词： | 三环类药物 人参皂甙 抗抑郁作用 去甲肾上腺素 多巴胺 5-羟色胺 |
| 文章编号： | 1004-1842(2002)01-0037-02 |
| 修稿时间： | 2001年11月16 |
The Discussion of Tricyclines and Ginsenosides Effect on the Antidepressant Function |
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| NI Xiao-hu,GAO Shi-yong,SHI Xiaoli,AN Chun-zhi,BAI Jie.The Discussion of Tricyclines and Ginsenosides Effect on the Antidepressant Function[J].Journal of Harbin University of Commerce :Natural Sciences Edition,2002,18(1):37-38. |
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| Authors: | NI Xiao-hu GAO Shi-yong SHI Xiaoli AN Chun-zhi BAI Jie |
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| Abstract: | This literary graced the forced swimming test to observe tricyclines and ginseno-sides by law with the rats.To its in the cerebrum nerve pass monoamine uality(noradrenaline,dopamine,5-hydroxytrypamine)went on ration determine,in order to solve its functon fur-ther bright and divide only to the rats NA in the cerebrum,DA,and5-TH content deter-mine mere degrees of law with fluorescence.The result showed that tricyclines and ginseno-sides had obvious effected on the antidepressant function(P<0.01)and the forming of the de-pression were related to the content of NA,DA,5-HT in rats cerebrum. |
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| Keywords: | tricyclines ginsenosides antidepressant effet forced swimming test nora-drenaline dopamine 5-hydroxytrypamine |
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