| 功劳木有效成分逆转肿瘤多药耐药研究 |
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| 引用本文： | 丛悦,郭敬功,王天晓,王艳,王世广,刘静.功劳木有效成分逆转肿瘤多药耐药研究[J].河南大学学报(自然科学版),2012,42(1):83-86. |
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| 作者姓名： | 丛悦 郭敬功 王天晓 王艳 王世广 刘静 |
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| 作者单位： | 1. 河南大学 药物研究所,河南开封,475004
2. 河南大学 植物逆境生物学重点实验室,河南开封,475004 |
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| 基金项目： | 河南省科技厅基础与前沿技术研究项目，河南省教育厅项目，河南大学校内项目 |
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| 摘 要： | 采用高内涵活细胞成像系统检测功劳木10种有效成分对肿瘤细胞K562/ADM细胞内罗丹明(rhodamine123,Rh123)蓄积的影响,结果发现化合物2-9可以不同程度地提高K562/ADM细胞中Rh123的荧光强度(给药浓度为10μmol/L时,Rh123荧光强度增长率分别为15.19%、24.01%、8.70%、73.17%、21.84%、76.98%、17.26%和23.29%).结果表明化合物2-9均具有逆转肿瘤多药耐药活性,其中化合物7的抗多药耐药活性最强.
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| 关 键 词： | 功劳木 活性成分 多药耐药 肿瘤细胞 |
Reversal of Multidrug Resistance of Tumor Cells by Components from the Stem of Mahonia bealei |
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| CONG Yue
,
GUO Jing-gong
,
WANG Tian-xiao
,
WANG Yan
,
WANG Shi-guang
,
LIU Jing.Reversal of Multidrug Resistance of Tumor Cells by Components from the Stem of Mahonia bealei[J].Journal of Henan University(Natural Science),2012,42(1):83-86. |
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| Authors: | CONG Yue GUO Jing-gong WANG Tian-xiao WANG Yan WANG Shi-guang LIU Jing |
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| Institution: | a(Henan University a.Institute of Pharmacy b.The Key Laboratory of Plant Stress Biology, Henan Kaifeng 475004,China) |
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| Abstract: | To research reversal of multidrug resistance by 10 compounds from the stem of Mahonia bealei(Fort.) Carr.,the effects of 10 compounds on rhodamine123 accumulation in K562/ADM cells were detected by high content screening analysis.Compound 2-9 can raise mean fluorescence intensity(MFI) of rhodamine123 in K562/ADM cells by different degrees(MFI increasing rate of Rh123 were 15.19 %,24.01 %,8.70%,73.17 %,21.84 %,76.98 %,17.26 % and 23.29 % at a concentration of 10 μmol/L respectively).Compound 2-9 possess the reversal of multidrug resistance activity,among which compound 7 was the strongest. |
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| Keywords: | Mahonia bealei active constituent multidrug resistance tumor cells |
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