石油化工污水对成年小鼠、妊娠小鼠及其胎鼠的遗传毒性研究

本文用整体微核试验对石油化工污水及厂区饮用水进行遗传毒性研究。观察成年小鼠、孕鼠及其胎鼠在不同生理状态下微核率的变化。实验结果表明:厂区饮用水对成年小鼠影响不大。而对孕鼠及胎鼠则引起微核频率的增加。污水对成年小鼠、孕鼠及胎鼠均可引起微核率升高,呈明显的阳性结果。其敏感顺序是胎鼠>孕鼠>成年小鼠。3种待测水样遗传毒性顺序为1号污水J>蓄存库水N>饮用水S。结果表明,石油化工污水对小鼠有较强的诱变活性。饮用水受到不同程度的污染。

Genetic Toxicity of Petrochemical Sewage on Adult and Pregnant Mice and Their Fetus

In order to exploit cheap irrigation water resources for farmland irrigation the utilization of urban waste water has heen developed during recent years. Whereas nearly 85% urban industrial waste water, for instance petrochemical sewage, has not beea thoroughly purified before drainaged to the irriagation system.In this study the adult mice, pregnant mice and their fetus were treated with petrochemical sewage J, reservoirs water N and tap water S to investigate their genetic toxicity on the above animals. The results showed that in adult mice there are no significant differences in micronucleus frequency between tap water S group, reservoirs, water N group and the control group. However, the pregnant mice with its fetus showed some mutagenic activity. After treatment, there are a very significant difference (P< 0.001) between the control and the petrochemical sewage J groups.The magnitude sequence of mutagenic activity of different waters is petrochemical sewage J>reservoirs water N>tap water S. The magnitude sequence of sensitive animal to the toxic effect is Fetus mice>pregnant mice>Adult.