癌细胞和正常细胞熵产生的对比分析及在癌症治疗中的应用

依据非平衡热力学,对细胞内的熵产生率进行了计算,并对癌细胞和正常细胞的熵产生进行了对比分析,证明了在通常条件和无外场作用情况下,癌细胞的熵产生率高于正常细胞.但在电场和超声场作用下有可能使正常细胞获得较高的熵产生,因而发生熵流方向的倒转.考虑到信息量是熵在高维相空间中向低维子空间的投影,熵流方向倒转将避免癌细胞的有害信息向周围正常组织的扩散.提出利用方波脉冲电场和低频低强度超声场于癌症理疗的可能性.

Comparative Studies on Entropy Production in Cancerous and Normal Cells and its Application in Cancer Treatment

Based on the thermodynamics on irreversible processes the entropy production rates are calculated for cancer and normal cells respectively.The relative importance of various contributions of entropy production is compared with each other.It is demonstrated that the entropy production rate of cancerous cell is always higher than healthy cell apart from the case of external field applied.Different entropy production rates between two kinds of cells determine the direction of entropy flow among cells.The entropy flow from cancers to healthy cells would take along the harmful information of cancerous cell,propagating its toxic action to healthy tissues.We have proved that an applied electric field(square wave electric pulse) or a low frequency and low intensity ultrasound irradiation may induce increasing entropy production rate in normal tissue around the tumor,consequently reverse the direction of entropy current.This provides a new insight into cancer therapy and can be used as a diagnostic tool.