| 阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察 |
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| 引用本文： | 李佳琳,孟萍,刘春年,颜承云.阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质考察[J].长春师范学院学报,2012(6):24-26. |
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| 作者姓名： | 李佳琳 孟萍 刘春年 颜承云 |
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| 作者单位： | 佳木斯大学药学院 |
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| 基金项目： | 黑龙江省自然科学基金项目(D201054) |
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| 摘 要： | 考察阿昔洛韦/赖氨酸壳聚糖纳米粒的理化性质。利用激光粒度分析仪、透射电镜、扫描电镜、高效液相色谱仪等测定载药纳米粒的形态、粒径、包封率和载药量,并考察载药纳米粒的体外释放行为。考察结果,微球呈类圆形,具有明显的核壳;载药的粒子平均粒径大小为107.96 nm;包封率为(61.24±0.68)%;载药量为(15.36±0.65)%;体外释放符合Higuchi模型。结论:阿昔洛韦/赖氨酸壳聚糖纳米粒理化性能具有良好的稳定性,符合实验设计要求。
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| 关 键 词： | 三草酸合铁(Ⅲ)酸钾 合成 优化 |
Evaluation of Physicochemical Properties for Acyclovir/Lysine-chitosan Nanoparticles in Vitro |
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| LI Jia-lin,MENG Ping,LIU Chun-nian,YAN Cheng-yun.Evaluation of Physicochemical Properties for Acyclovir/Lysine-chitosan Nanoparticles in Vitro[J].Journal of Changchun Teachers College,2012(6):24-26. |
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| Authors: | LI Jia-lin MENG Ping LIU Chun-nian YAN Cheng-yun |
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| Institution: | (Pharmacy College of Jiamusi University,Jiamusi 154007,China) |
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| Abstract: | Objective: To investigate physical and chemical properties of nanoparticles.Methods: Using laser particle size analyzer,transmission electron microscope,scanning electron microscope and high performance liquid chromatograph to determin the form,particle size,entrapment efficiency and drug loading of drug-loaded nanoparticles,and investigate its release behavior.Results: The nanoparticles was spherical with obvious nuclear shell,the nanoparticles had average diameter of 107.96nm,entrapment efficiency of(61.2±0.68)%,drug loading capacity of(15.36±0.65)%,and the in virto release effect was true of Higuchi equation.Conclusion: The particle stability of acyclovir lysine-chitosan nanoparticles was tranquilization. |
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| Keywords: | Acyclovir Lysine-chitosan nanoparticles physical and chemical properties |
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