| 自发曲率对受体介导的胞吞作用的影响 |
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| 引用本文： | 时文东.自发曲率对受体介导的胞吞作用的影响[J].清华大学学报(自然科学版),2009(2). |
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| 作者姓名： | 时文东 |
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| 作者单位： | 清华大学工程力学系; |
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| 基金项目： | 国家自然科学基金资助项目(10525210,10121202) |
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| 摘 要： | 为研究纳米颗粒进入具有自发曲率的细胞膜的机理,在已建立的受体介导胞吞作用力学模型的基础上进行了扩展,对非零自发曲率的细胞膜上发生的受体介导的胞吞作用进行了研究。结果显示:包裹时间不仅依赖于颗粒的尺寸,而且依赖于细胞膜的自发曲率;存在最佳的颗粒半径使包裹时间最短;对于无限大尺寸的细胞膜,当细胞膜的自发曲率大于临界值时,存在最小和最大包裹半径,但当细胞膜的自发曲率小于等于临界值时,只存在最小包裹半径。
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| 关 键 词： | 生物力学 细胞粘附 受体介导的胞吞作用 |
The effect of spontaneous membrane curvature on receptor-mediated endocytosis |
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| SHI Wendong.The effect of spontaneous membrane curvature on receptor-mediated endocytosis[J].Journal of Tsinghua University(Science and Technology),2009(2). |
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| Authors: | SHI Wendong |
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| Institution: | Department of Engineering Mechanics;Tsinghua University;Beijing 100084;China |
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| Abstract: | Based on the mechanical model of receptor-mediated endocytosis,the effect of a spontaneous membrane curvature induced by clathrin or caveolin coats at the inner membrane leaflet was investigated,which is of interest to understanding mechanisms by which nanomaterials might enter into human or animal cells.The results shows that not only the particle size but also the spontaneous membrane curvature can affect the endocytic time;there exists an optimal particles size for the smallest wrapping time;for infinite... |
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| Keywords: | biomechanics cell adhesion receptor-mediated endocytosis |
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