Molecular docking and spectroscopic methods to probe the interaction of acetylgliotoxin and HSA |
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Authors: | Lianru Zhang Junjie Chen Siyang Song Zhonghui Zheng Yaojian Huang |
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Institution: | 1.School of Life Sciences,Xiamen University,Xiamen,Fujian, China |
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Abstract: | The interaction between acetylgliotoxin and human serum albumin (HSA) has been studied by spectroscopic method. Acetylgliotoxin
quenches the intrinsic fluorescence of HSA in a static quenching procedure. The binding of acetylgliotoxin to HSA causes a
slight conformational change of HSA. The binding constants at different temperatures as well as enthalpy change and entropy
change, are calculated according to relevant fluorescent data and Van’t Hoff equation. The hydrogen bond is a predominant
intermolecular force for stabilizing the complex, which is in conformity with the results of molecular modeling study. |
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