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Synthesis of 2,4-dibromo-5-fluorobenzonitrile |
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| Authors: | Zheng Qiong Huang Chi Xu Chongwen Xie Guangyong Chen Yuanyin |
| Institution: | (1) College of Chemistry, Wuhan University, 430072 Wuhan, China |
| Abstract: | 2,4-Dibromo-5-fluorobenzonitrile has been synthesized for the first time (81.5% yield). It may be used in synthesizing 2,4-dibromo-5-fluorobenzoic acid, the intermediates of fluoroquinolones. The ammoxidation procedure for preparation of the nitrile has been described in detail. Zheng Qiong: born in 1945, Associate professor |
| Keywords: | ammoxidation 2 4-dibromo-5-fluorobenzonitrile 2 4-dibromo-5-fluorobenzoic acid fluoroquinolone |
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