| Study on Non-Isothermal Decomposition Kinetics of Ephedrini Hydrochloridum |
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| 作者姓名： | Tang Wan-jun Chen Dong-hua Sheng Yu-fang
College of Chemistry and Molecular Sciences Wuhan University Wuhan Hubei China College of Chemistry and Life Sciences South-Central University for Nationality Wuhan Hubei China |
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| 作者单位： | Tang Wan-jun，Chen Dong-hua，Sheng Yu-fang
College of Chemistry and Molecular Sciences，Wuhan University，Wuhan 430072，Hubei，China;
College of Chemistry and Life Sciences，South-Central University for Nationality，Wuhan 430074，Hubei，China |
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| 基金项目： | the Foundation of the Science and Technology Committee of Hubei Province(2001ABA009) |
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| 摘 要： | The thermal decomposition processes of ephed-rini hydrochloridum and its kinetics are studied by TG-DTG techniques. A combined method, which includes Achar method, Coats-Redfern method, and Ozawa method, is put forward for determining kinetic model under non-isothermal conditions. By applying the combined method, it is determined that the thermal decomposition of ephedrini hydrochloridum is subjected to cylindrical symmetric diffusion. And the reactionfunction is f(α) = 2(1 -α)1/2 , apparent activation energy (115. 26±3. 55) kJ·mol-1 , pre-exponential factor 4. 62×108 s-1. Results show that the combined method is feasible and simple.
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Study on non-isothermal decomposition kinetics of ephedrini hydrochloridum |
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| Tang Wan-jun,Chen Dong-hua,Sheng Yu-fang
College of Chemistry and Molecular Sciences,Wuhan University,Wuhan ,Hubei,China,
College of Chemistry and Life Sciences,South-Central University for Nationality,Wuhan ,Hubei,China.Study on Non-Isothermal Decomposition Kinetics of Ephedrini Hydrochloridum[J].Wuhan University Journal of Natural Sciences,2003,8(2):443-446. |
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| Authors: | Tang Wan-jun Chen Dong-hua Sheng Yu-fang |
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| Institution: | (1) College of Chemistry and Molecular Sciences, Wuhan University, 430072 Wuhan, Hubei, China;(2) College of Chemistry and Life Sciences, South-Central University for Nationality, 430074 Wuhan, Hubei, China |
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| Abstract: | The thermal decomposition processes of ephed-rini hydrochloridum and its kinetics are studied by TG-DTG techniques. A combined method, which includes Achar meth-od, Coats-Redfern method, and Ozawa method, is put for-ward for determining kinetic model under non-isothermal con-ditions. By applying the combined method, it is determined that the thermal decomposition of ephedrini hydrochloridum is subjected to cylindrical symmetric diffusion. And the reaction function is f(α) = 2(1 - α)1/2, apparent activation energy(115. 26±3.55) kJ @ mol-1 , pre-exponential factor 4. 62 ×108 s-1. Results show that the combined method is feasible and simple. |
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| Keywords: | ephedrini hydrochloridum TG-DTG tech-nique non-isothermal kinetics combined method thermal decomposition |
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