| The Effect of cdk-5 Overexpression and Overactivation on Tau Hyperphosphorylation in Cultured N2a Cells |
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| 作者姓名： | CHEN Juan LI Hong-lian FENG You-mei WANG Jian-zhi . |
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| 作者单位： | CHEN Juan 1，LI Hong-lian 2，FENG You-mei 1，WANG Jian-zhi 2 1.Department of Biochemistry and Molecular Biology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China; 2.Department of Pathophysiology，Tongji Medical College，Huazhong University of Science and Technology，Wuhan 430030，China |
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| 基金项目： | Supported by the National Natural Science Foundation of China (39925012，30100057，30170221)，the Science and Technology Founda tion Committee Foundurion of China(G1999054007) and National Youth Sci ence Foundation of China(39925012) |
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| 摘 要： | 0 IntroductionNeurofibrillary tangle, primarily composed of thehyperphosphorylated microtubule associatedprotein tau1], is one of the major neuropathologichallmarks in Alzheimar’s disease (AD). In affectedneurons, the major mechanism o…
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| 关 键 词： | cyclin-dependent kinase5 (Cdk-5) tau Alzheimer’s diseas |
The Effect of cdk- 5 Overexpression and Overactivation on Tau Hyperphosphorylation in Cultured N2a Cells |
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