| 法罗培南钠片含量测定方法的研究 |
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| 引用本文： | 林林,胡秋杰.法罗培南钠片含量测定方法的研究[J].科技资讯,2014,12(18):191-192. |
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| 作者姓名： | 林林 胡秋杰 |
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| 作者单位： | 1. 黑龙江省食品药品检验检测所 黑龙江哈尔滨 150001
2. 黑龙江生物科技职业学院 黑龙江哈尔滨 150025 |
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| 基金项目： | 黑龙江省教育厅高职高专院校科学技术研究项目《法罗培南钠片的药学研究》 |
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| 摘 要： | 目的建立法罗培南钠片含量测定方法。方法色谱柱:Agilent-150 mm XDB-C18 5μm;流动相:乙腈-磷酸二氢钾缓冲液(20 mmol/L磷酸二氢钾水溶液,用10 mol/L NaOH溶液调pH值至6.0)(10∶90);柱温:30℃;检测波长为256 nm;流速:1 ml/min;进样量:20μl。结果法罗培南钠在0.10~0.99 mg/ml浓度范围内线性关系良好,A=2.4127E+07C-20998;相关系数r=0.9999。重复性、精密度及耐用性良好,定量限为3.58μg/ml。结论本方法准确、可靠、专属性强,可以更好的控制产品质量。
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| 关 键 词： | 法罗培南钠 高效液相 含量测定 |
Method Research for the Determination of Sodium Faropenem Tablets |
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| Lin Lin,Hu Qiujie.Method Research for the Determination of Sodium Faropenem Tablets[J].Science & Technology Information,2014,12(18):191-192. |
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| Authors: | Lin Lin Hu Qiujie |
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| Institution: | Lin Lin Hu Qiujie (1. The Heilongjiang Provincial Food and Drug Inspection Institute, Harbin Heilongjiang, 150001, China; 2. Heilongjiang Biological Technology Career Academy,Harbin Heilongjiang, 150025,China) |
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| Abstract: | Object An HPLC method was established for the identification of the assay in sodium faropenem.HPLC separation was carried out on Agilent ODS-3 column（250 mm×4.6 mm,5μm）with a mobile phase：acetonitrile--phosphate buffer（20 mmol/L potassium dihydrogen phosphate solution,with 10 mol/L NaOH solution adjusted to pH 6.0）（10：90）;detection wavelength was 256 nm and flow rate was 1 ml/minsinjection volume was 20 μl.Results there is a good linear relationship in 0.10--0.99 mg/ml,A=2.4127E＋07C-- 20998,r=0.9999 trepeatability,precision,and durability is good,the limit of quantification was 3.58 μ g/ml. Conclusion The estab- lished method is effective in the separation and identification of the related substances in faropenem sodium and the results are useful for its quality control. |
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| Keywords: | Faropenem Sodium HPLC Determination of Content |
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