| 盐酸地尔硫卓延迟释药微丸体外释放研究 |
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| 引用本文： | 王雪洁,朱喜梅.盐酸地尔硫卓延迟释药微丸体外释放研究[J].科技资讯,2013(13):204-204,206. |
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| 作者姓名： | 王雪洁 朱喜梅 |
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| 作者单位： | 天方药业二分厂药物研究所 河南驻马店 463000 |
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| 摘 要： | 测定盐酸地尔硫卓延迟缓释制剂的体外释放行为，为试药翻定释放度质量标准。采用体外释放度检查法，在pH值6．8介质中进行体外释放度测度，利用高效液相色谱进行检测。本制剂释放度复合延迟释放特点，可用于该药释放度质量标准制定。
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| 关 键 词： | 地尔硫卓 释放度 pH值 |
Release Character of Hydrochloride Diltiazem Delay-onset Sustained-release Pellet in vitro |
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| Xue-Jie Wang
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Xi-Mei Zhu.Release Character of Hydrochloride Diltiazem Delay-onset Sustained-release Pellet in vitro[J].Science & Technology Information,2013(13):204-204,206. |
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| Authors: | Xue-Jie Wang Xi-Mei Zhu |
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| Institution: | (Research Institute of Topfond Pharmaceutical Corp; Zhumadian Henan,463000,China) |
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| Abstract: | To determine the release character of hydrochloride diltiazem delay--onset sustained--release pellet in vitro and establish its quality standard. Release character assay method was adopted according to the Chinese Pharmacopoeia（2010 edition）, in which the release medium was pH 6.8 phosphate buffer and detection instrument was HPLC. the release rate was well fitted to our designed criterion and this method can be adopted as its quality satandard. |
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| Keywords: | Diltiazem Release PH value |
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