| 乌索酸固体分散体的制备与分析 |
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| 引用本文： | 陈武,邹盛勤.乌索酸固体分散体的制备与分析[J].江西师范大学学报(自然科学版),2006,30(1):81-83. |
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| 作者姓名： | 陈武 邹盛勤 |
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| 作者单位： | 宜春学院,生物工程研究所,江西省天然药物活性成分研究重点实验室,江西,宜春,336000 |
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| 摘 要： | 采用聚乙烯吡咯烷酮(PVP-K30)作为载体,用溶剂法制备乌索酸(UA)固体分散体,以提高制剂中UA的溶出度;建立高效液相色谱(HPLC)法测定固体分散体的体外溶出度,并进行红外和紫外光谱分析,鉴别药物在载体中的存在状态.研究结果表明,HPLC法测定UA的溶出度准确可靠、稳定、无载体的干扰;选择PVP-K30作为载体制备成固体分散体,能显著地提高UA的体外溶出速度.
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| 关 键 词： | 乌索酸 聚乙烯吡咯烷酮 固体分散体 溶出度 高效液相色谱 |
| 文章编号： | 1000-5862（2006）01-0081-03 |
| 收稿时间： | 2006-09-06 |
| 修稿时间： | 2006-09-06 |
Preparation and Analysis of Solid Dispersion Systems of Usolic Acid |
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| CHEN Wu,ZOU Sheng-qin.Preparation and Analysis of Solid Dispersion Systems of Usolic Acid[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2006,30(1):81-83. |
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| Authors: | CHEN Wu ZOU Sheng-qin |
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| Institution: | Bioengineering Research Institute of Yichun University, Key Laboratory of Province for Research on Active Ingredients in Natural Medicines, Yichun Jiangxi 336000, China |
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| Abstract: | To enhance the dissolution rate of ursolic acid(UA) from its preparation,solid dispersion systems of UA in PVP-K30 were prepared at various weight ratios by co-evaporation of drug and PVP-K30 ethanol solution.The HPLC method were established to measure its external dissolusion rate.IR and UV spectral analysis were used to describe the status of drug in carriers.The result shows that HPLC method is accurate and reliable,and no interference occurs from carriers.The solid dispersion system in PVP-K30 can improve well the dissolution rate of ursolic acid. |
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| Keywords: | ursolic acid PVP-K30 solid dispersion system dissolution HPLC |
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