| 基于随机矩阵理论分析乳腺癌基因网络 |
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| 引用本文： | 李蓉,郑浪,任喜梅,刘超飞.基于随机矩阵理论分析乳腺癌基因网络[J].江西师范大学学报(自然科学版),2020,44(5):495-500. |
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| 作者姓名： | 李蓉 郑浪 任喜梅 刘超飞 |
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| 作者单位： | 1.华东交通大学理工学院,江西 南昌 330100; 2.江西省教育考试院,江西 南昌 330038; 3.江西理工大学理学院物理电子系,江西 赣州 341000 |
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| 基金项目： | 江西省教育厅科学技术研究项目;江西省高等学校教学改革研究项目;国家自然科学基金 |
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| 摘 要： | 利用随机矩阵理论分析乳腺癌基因微阵列数据,得到乳腺癌基因共表达网络,找出乳腺癌基因共表达网络中重要的增殖模块和免疫模块,并预测基因PMSCL1与乳腺癌细胞的增殖、侵袭及迁移有关,基因CCAN2与乳腺癌细胞的有丝分裂有关,基因SCYA5与乳腺癌细胞的免疫应答有关,基因PRC1、RAB31、INHBA可作为乳腺癌的靶向基因.
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| 关 键 词： | 随机矩阵理论 乳腺癌 基因共表达网络 模块 靶向基因 |
The Study of Breast Cancer Gene Network Based on Random Matrix Theory |
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| LI Rong,ZHENG Lang,REN Ximei,LIU Chaofei.The Study of Breast Cancer Gene Network Based on Random Matrix Theory[J].Journal of Jiangxi Normal University (Natural Sciences Edition),2020,44(5):495-500. |
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| Authors: | LI Rong ZHENG Lang REN Ximei LIU Chaofei |
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| Institution: | 1.Institute of Technology,East China Jiaotong University,Nanchang Jiangxi 330100,China; 2.Jiangxi Provincial Education Examination Authority,Nanchang Jiangxi 330038,China; 3.Jiangxi University of Science and Technology,Ganzhou Jiangxi 341000,China |
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| Abstract: | By using random matrix theory,the breast cancer gene microarray data is analyzed.The proliferation and immune modules of breast cancer gene are found out from breast cancer gene express network.Meanwhile,it is shown that the gene PMSCL1 is related to breast cancer cell proliferation,invasion and migration,gene CCAN2 is related to the Mitosis of breast cancer cells,gene SCYA5 is related to immune response of breast cancer cells and gene PRC1,RAB31 and INHBA can be used as targeted genes for breast cancer treatment. |
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| Keywords: | random matrix theory breast cancer gene co-expression network module targeted gene |
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