| 加味四物汤降压作用及对左心室肥厚影响的实验研究 |
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| 引用本文： | 毛秉豫.加味四物汤降压作用及对左心室肥厚影响的实验研究[J].南阳理工学院学报,2009,1(6):88-92. |
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| 作者姓名： | 毛秉豫 |
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| 作者单位： | 南阳理工学院张仲景国医学院,河南,南阳,473004 |
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| 摘 要： | 本文研究了加味四物汤的降压作用及对左心室肥厚的影响。将自发性高血压大鼠（SHR）分为模型组、中药不同剂量组以及其它药物治疗组,测定用药后各时间期内的血压变化;并在用药前以及8周后分别观察左室肥厚相关指标和组织形态学变化。研究发现各剂量组血压均有不同程度的下降,各药物组的Ⅰ、Ⅲ胶原比例有不同程度的改善。结果表明：该方剂有明确的降压作用,并具有持续、平稳的特点;可减轻SHR左室肥厚,对较高血压水平造成的心脏损伤有一定保护作用。
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| 关 键 词： | 中医药疗法 加味四物汤 自发性高血压大鼠 左心室肥厚 |
EFFECT OF SUPPLEMENTED SIWU DECOCTION ON BLOOD PRESSURE AND LEFT VENTRICULAR HYPERTROPHY IN SHR |
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| MAO Bing-yu.EFFECT OF SUPPLEMENTED SIWU DECOCTION ON BLOOD PRESSURE AND LEFT VENTRICULAR HYPERTROPHY IN SHR[J].Journal of Nanyang Institute of Technology,2009,1(6):88-92. |
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| Authors: | MAO Bing-yu |
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| Institution: | MAO Bing-yu ( Zhang Zhongjing College of Traditional Chinese Medicine,Nanyang Institute of Technology,Nanyang 473004,China) |
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| Abstract: | The effect of supplemented Siwu decoction （ SSWD） on blood pressure and left ventricular hypertrophy of spontaneous hypertension rats （ SHR） is studied. Sixty SHR are randomly divided into six groups. SBP and left ventricular mass（ LVM） ,the left ventricular mass index（ LVMI） ,the content of left ventricular myocardical interstitial collagen and the collagen ratio of typeⅠto type Ⅲ at different dose groups of SSWD and model group are measured. The results show the antihypertensive effects of SSWD is efficient and lasting,and do for the target organs damages associated with hypertension. |
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| Keywords: | Supplemented Siwu decoction SHR Blood pressure Left ventricular hypertrophy |
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