| （±）-SepicaninA的首次全合成 |
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| 引用本文： | 黄文倩,杨金会,郭冬冬,落俊山.（±）-SepicaninA的首次全合成[J].宁夏大学学报(自然科学版),2012,33(3):270-273. |
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| 作者姓名： | 黄文倩 杨金会 郭冬冬 落俊山 |
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| 作者单位： | 宁夏大学天然气转化国家重点实验室培育基地,宁夏银川,750021 |
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| 基金项目： | 国家自然科学基金资助项目(20962016,21162021);教育部“新世纪优秀人才支持计划资助”基金资助项目(NCET-09-0860);宁夏自然科学基金资助项目(NZ1006) |
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| 摘 要： | 以,2，4，6-三羟基苯乙酮和2，4－二羟基苯甲醛为原料，经4步以总收率16％得到最终产物——香叶基黄烷酮（±）SepicaninA．合成的关键步骤是质子酸催化查尔酮形成苯并吡喃酮的同时脱去羟基保护基，一步得到目标产物（士）SepicaninA。所有新化合物的结构都经过1H－NMR，IR，MS分析表征．
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| 关 键 词： | （±）-Sepicanin A 黄烷酮 香叶基黄烷酮 全合成 |
Total Synthesis of (±)-Sepicanin A |
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| Huang Wenqian
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Yang Jinhui
,
Guo Dongdong
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Luo Junshan.Total Synthesis of (±)-Sepicanin A[J].Journal of Ningxia University(Natural Science Edition),2012,33(3):270-273. |
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| Authors: | Huang Wenqian Yang Jinhui Guo Dongdong Luo Junshan |
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| Institution: | (State Key Laboratory Cultivation Base of Natural Gas Conversion,Ningxia University,Yinchuan 750021,China) |
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| Abstract: | A facile approach for the first total synthesis of naturally occurring geranylated flavanoids sepicanin A has been obtained with total yield 16% starting from 2,4,6-trihydroxyacetophenone after four steps.The key step was the protic acids(HCl or p-TsOH)-catalyzed benzopyrone formation in a protic polar solvent by deprotection and cyclization of chalcone in one step.All structures of new compounds were confirmed by IR,1H NMR and MS. |
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| Keywords: | sepicanin A flavanone geranylated flavonoids total synthesis |
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