隔药灸神阙对耐力训练再力竭运动大鼠心肌、骨骼肌自由基代谢的影响

以SD大鼠为研究对象,建立耐力训练再力竭运动大鼠模型,通过测定不同组别大鼠心肌、骨骼肌中SOD、CAT、GSH-Px活性及MDA含量的变化,探讨隔药灸神阙对耐力训练再力竭运动大鼠心肌、骨骼肌自由基代谢的影响.结果显示,训练隔药灸组大鼠心肌、骨骼肌中SOD、CAT、GSH-Px活性均显著高于训练组(P<0.05),GSH-Px活性与安静组比较无差异(P>0.05);MDA含量显著低于训练组(P<0.05),与安静组比较无差异(P>0.05).由此提示,隔药灸神阙可减轻耐力训练再力竭运动对大鼠心肌、骨骼肌造成的脂质过氧化损伤,改善运动造成的机体自由基代谢紊乱,从而明显延长耐力训练大鼠力竭时间.

Effects of Medicine-separated Moxibustion on Free Radical of Myocardia and Skeletal Muscle in Endurance-trained Rats after Exhaustive Exercise

The model was set up through endurance-trained administration of SD mice. Effects of the medicine-separated moxibustion on the free radical of myocardia and skeletal muscle were observed, the indices included the activity of SOD, CAT and GSH-Px, the concentration of malondialdehyde (MDA). The results show that the activity of SOD, CAT and GSH-Px in myocardia and skeletal muscle of the training-medicine-separated moxibustion group are higher than that of the training group (P＜0.05), the activity of GSH-Px is insignificantly different with the controlling group (P＞0.05); the concentration of MDA is remarkable lower than that of the training group (P＜0.05), but is insignificantly different with the controlling group (P＞0.05). The results suggest that the medicine-separated moxibustion on Shenque can relieve the damage of the lipid peroxidation in endurance-trained mice after exhaustive exercise, improve the metabolism confusion of free radical caused by sports, and prolong the exhaustive time significantly in endurance-trained mice.