抗干扰性智能索拉菲尼隐形印迹材料的制备及其释药性能研究

将分子印迹技术和隐形纳米技术相结合,用亲水性聚乙二醇对索拉菲尼印迹聚合物进行隐形化修饰,制备了具有抗干扰性能的智能索拉菲尼隐形印迹材料。研究发现该材料对含NaCl、KCl盐溶液具有较好的抗干扰性,当Na⁺、K⁺分别与索拉菲尼共存时,目标材料对索拉菲尼的吸附容量仅下降8.6%及19.2%。不仅如此,目标材料还对索拉菲尼现出良好的特异选择性,相对瑞戈非尼和甜菜碱而言,其分离因子各为2.33、4.63。释药性能结果表明,目标材料不仅在模拟肿瘤环境(pH为5.5)的累积释药率41.42%要明显高于在正常生理环境(pH为7.4)条件下的27.71%,而且于还原性物质谷胱甘肽存在的情况下,无论pH值为5.5还是7.4时,目标材料的药物累积释放率均显著增大,分别为63.77%及39.15%。目标印迹材料对索拉菲尼的缓释效果也不错,时长可达160 h。

Preparation and Drug Release Performance of Smart Sorafenib Stealth Imprinted Material with Anti-interference Property

Combining molecular imprinting technology with stealth nanotechnology, sorafenib imprinted polymer was stealthly modified by hydrophilic polyethylene glycol, and an intelligent sorafenib stealth imprinting material S-SMIP with anti-interference performance was prepared. It was found that this material had good anti-interference ability to salt solution. When Na⁺ and K⁺ coexist with sorafenib, the adsorption capacity of sorafenib decreased by only 8.6% and 19.2% respectively, and the specific selectivity was also high. The separation factors for regafinib and betaine were 2.33 and 4.63 respectively. In addition, the drug release rate of 41.42% in the simulated tumor environment at pH5.5 was significantly higher than that of 27.71% in the normal physiological environment at pH7.4, and the cumulative drug release rate increased significantly at pH5.5 and pH7.4 under reducing glutathione, which were 63.77% and 39.15% respectively. Sorafenib release time in S-SMIP was also good, up to 160 h.