Cellular response to titanium discs coated with polyelectrolyte multilayer films |
| |
| Authors: | Jing Zhan Qiao-jie Luo Ying Huang Xiao-dong Li |
| |
| Institution: | 1. Department of Stomatology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, 310016, China
2. Department of Oral and Maxillofacial Surgery, the Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou, 310031, China
|
| |
| Abstract: | The purpose of this study was to investigate the effects of polyelectrolyte multilayer (PEM) coatings on the biological behavior of titanium (Ti) substrates. Collagen type Ι/hyaluronic acid (Col/HA) and chitosan/hyaluronic acid (Chi/HA) multilayer PEM coatings were introduced onto Ti substrates using layer-by-layer assembly. Contact angle instruments and quartz crystal microbalance were used for film characterization. The results obtained showed that both Col/HA and Chi/HA surfaces had high hydrophilicity and promoted cell adhesion in MC3T3-E1 pre-osteoblast and human gingival fibroblast cells. In addition, the synthesis of function-related proteins and gene expression levels in both MC3T3-E1 and fibroblast cells was higher for the Col/HA coating compared with the Chi/HA coating, indicating better cellular response to the Col/HA coating. |
| |
| Keywords: | |
| 本文献已被 万方数据 SpringerLink 等数据库收录！ |
| 点击此处可从《矿物冶金与材料学报》浏览原始摘要信息 |
| 点击此处可从《矿物冶金与材料学报》下载免费的PDF全文 |
|
