| FeSOD天然酶活性中心的理论研究 |
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| 引用本文： | 杨彦杰,郑学仿,蒋革,唐乾,曹洪玉.FeSOD天然酶活性中心的理论研究[J].东北师大学报(自然科学版),2007,39(1):77-80. |
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| 作者姓名： | 杨彦杰 郑学仿 蒋革 唐乾 曹洪玉 |
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| 作者单位： | 大连大学生物工程学院,辽宁省高校生物有机化学重点实验室,辽宁,大连,116622 |
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| 摘 要： | 通过密度泛函理论计算,探讨FeSOD天然酶氧化态、还原态和失活态的活性中心的电子结构,揭示具有较高的结构稳定性和催化超氧阴离子的活性的原因.为FeSOD模拟化合物的分子设计提供了重要的信息.
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| 关 键 词： | 酶 密度泛函理论 |
| 文章编号： | 1000-1832（2007）01-0077-04 |
| 收稿时间： | 2006-10-20 |
| 修稿时间： | 10 20 2006 12:00AM |
Theoretical study on active sites of natural iron-containing superoxide dismutase |
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| YANG Yan-jie,ZHENG Xue-fang,JIANG Ge,TANG Qian,CAO Hong-yu.Theoretical study on active sites of natural iron-containing superoxide dismutase[J].Journal of Northeast Normal University (Natural Science Edition),2007,39(1):77-80. |
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| Authors: | YANG Yan-jie ZHENG Xue-fang JIANG Ge TANG Qian CAO Hong-yu |
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| Institution: | College of Bioengineering, Dalian University; Liaoning Key Laboratory of Bio-Organie Chemistry, Dalian 116622, China |
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| Abstract: | The electronic structures of the FeSOD active site in its oxidized,reduced an inactive states were explored by density functional theory,revealing the reason that the active forms is stable and susceptible to accept the electronic on superoxide anion radical to accomplish the physiological function.The result can be in favor of the design of SOD mimics. |
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| Keywords: | SOD |
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