| 纤维素键合手性柱拆分分析吲达帕胺对映体 |
| |
| 引用本文： | 周婕,刘倩,闫振,张振中.纤维素键合手性柱拆分分析吲达帕胺对映体[J].郑州大学学报(自然科学版),2013(2):95-98. |
| |
| 作者姓名： | 周婕 刘倩 闫振 张振中 |
| |
| 作者单位： | [1]郑州大学药学院,河南郑州450001 [2]药物关键制备技术省部共建重点实验室,河南郑州450001 |
| |
| 摘 要： | 建立一种用新型键合纤维素手性固定相拆分吲达帕胺对映异构体的高效液相色谱方法．使用ChiralpakIC（250mm×4．6mm，5μm）色谱柱拆分吲达帕胺对映体，分离度为1．98，流动相为正己烷一异丙醇（60／40，V／V），流速1．0mL／min，检测波长240nm，柱温25℃．
|
| 关 键 词： | 手性固定相 对映体拆分 吲达帕胺 高效液相色谱 |
Separation of Indapamide Enantiomers on a New Cellulose Bonded Chiral Stationary Phase |
| |
| ZHOU Jie,LIU Qian,YAN Zhen,ZHANG Zhen-zhong.Separation of Indapamide Enantiomers on a New Cellulose Bonded Chiral Stationary Phase[J].Journal of Zhengzhou University (Natural Science),2013(2):95-98. |
| |
| Authors: | ZHOU Jie LIU Qian YAN Zhen ZHANG Zhen-zhong |
| |
| Institution: | 1. School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, China ; 2. Key Laboratory of State Ministry of Education for Pharmaceutical Technology, Zhengzhou 450001, China) |
| |
| Abstract: | To develop a liquid chromatographic method for the chiral separating enantiomers of indapam- ide, indapamide enantiomers were separated by a Chiralpak IC （250 mm×4.6mm,5μm） at 25 ℃ and detected at 240 nm, the mobile phase used was n-hexane-isopropanol （60/40, V/V） at a flow rate of 1.0 mL/min. And the resolution was 1.98 . |
| |
| Keywords: | chiral stationary phase enantiomeric separation indapamide HPLC |
| 本文献已被 维普 等数据库收录！ |
