O-季铵化-N-水杨醛壳聚糖席夫碱的合成及抗菌性研究

以缩水甘油三甲基氯化铵（GTMAc）和水杨醛为改性剂,在羟基和氨基上分别引入季铵盐基团和席夫碱基团,合成得到含双抗菌功能基团的水溶性壳聚糖衍生物：O-季铵化-N-水杨醛壳聚糖席夫碱,并通过FTIR谱图、季铵化度的测定对壳聚糖衍生物结构进行表征.对合成条件进行了探讨,得到最佳的反应条件为：n（壳聚糖席夫碱）∶n（GTMAc）=1∶5,温度为70℃,时间为24 h,此时获得O-季铵化-N-水杨醛壳聚糖席夫碱的季铵化度和产率最佳,分别为93.7%和81.8%.将产物应用于棉织物抗菌整理,以5%O-季铵化-N-水杨醛壳聚糖席夫碱整理的织物对大肠杆菌和金黄色葡萄球菌的抗菌率分别达99.3%和94.0%以上.但该整理织物的耐洗性较差,经20次皂洗后基本失去抗菌性.

Study on Synthesis and Antibacterial Property of O-Quaternary Ammonium-N-Salicylaldehyde Chitosan Schiff Base

A dual-functional water-soluble chitosan derivative,O-quaternary ammonium-N-salicylaldehyde chitosan Schiff base is synthesized by introducing quaternary ammonium group and Schiff base group into 6-hydroxyl and 2-amino groups with glycidyl trimethyl ammonium chloride and salicylaldehyde as modifiers.The structures and degree of quaternization of the product are tested.Synthetic conditions are discussed and the best Quaternization degree（93.7%） and the highest yield（81.8%） of O-Quaternized chitosan-N-salicylaldehyde chitosan Schiff base under the conditions of chitosan schiff base 5：1（molar ratio）,70 ℃ and 24 h are obtained.Then the modified chitosan is used as antimicrobial finishing of cotton fabrics and antimicrobial activities of finished fabrics are tested on E.coli and S.aureus.The result shows that the finished fabrics have good antibacterial property and the inhibiting efficiency is 99.3% and 94.0% respectively,when finished with 5% modified chitosan.But laundry resistance of antibacterial finishing of cotton fabrics is poor.The cotton fabrics lose its antibacterial properties after being washed 20 times in soap.