| 新的糖/茂钛化合物的合成及其生物活性研究 |
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| 引用本文： | 朱湛,郭炳南,王亚利,窦晶晶,许施卓.新的糖/茂钛化合物的合成及其生物活性研究[J].北京理工大学学报,2012,32(5):531-534. |
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| 作者姓名： | 朱湛 郭炳南 王亚利 窦晶晶 许施卓 |
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| 作者单位： | 北京理工大学原于分子簇科学教育部重点实验室,北京,100081;北京理工大学原于分子簇科学教育部重点实验室,北京,100081;北京理工大学原于分子簇科学教育部重点实验室,北京,100081;北京理工大学原于分子簇科学教育部重点实验室,北京,100081;北京理工大学原于分子簇科学教育部重点实验室,北京,100081 |
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| 基金项目： | 国家自然科学基金资助项目(20871017) |
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| 摘 要： | 用4种含糖基团取代二氯化二茂钛中的氯,合成了4种新的糖/茂钛化合物:乳糖酸根一氯化二茂钛C12H21O12.C10H10TiCl,质酸根一氯化二茂钛C14H20NO11.C10H10TiCl.8H2O,乳糖酸根一质酸根二茂钛C12H21O12.C14H20NO11.C10H10Ti.26H2O和乳糖酸酰胺乙酸根一氯化二茂钛C14H24NO13C10H10TiCl.化合物都经过红外光谱、核磁共振、元素分析表征,并用MTT法研究了化合物对人体子宫颈癌细胞增殖体外实验.研究表明新合成的化合物都溶于水,对癌细胞有很好的抑制作用,糖结构的引入有明显的肝靶向效应.
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| 关 键 词： | 二氯化二茂钛 糖/茂钛化合物 子宫颈癌 肝癌 肝靶向 |
| 收稿时间： | 2011/10/21 0:00:00 |
Synthesis and Biological Activity of Titanocene Carbohydrate |
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| ZHU Zhan,GUO Bing-nan,WANG Ya-li,DOU Jing-jing and XU Shi-zhuo.Synthesis and Biological Activity of Titanocene Carbohydrate[J].Journal of Beijing Institute of Technology(Natural Science Edition),2012,32(5):531-534. |
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| Authors: | ZHU Zhan GUO Bing-nan WANG Ya-li DOU Jing-jing and XU Shi-zhuo |
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| Institution: | Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China;Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Institute of Technology, Beijing 100081, China |
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| Abstract: | Four new compounds of titanocene carbohydrate were synthesized by combining individual carbohydrate with Cp2TiCl2. They were C12H21O12·C10H10TiCl, C14H20NO11·C10H10TiCl·8H2O, C12H21O12·C14H20NO11·C10H10Ti·26H2O and C14H24NO13C10H10TiCl. All compounds were characterizated by IR, 1H-NMR spectroscopy and elemental analysis and were tested to examine the growth of uterine cancer cells. Biological experiments show that all presented compounds are dissolved easily in water and have better anti-tumor effects. In addition, the target affectation to liver of glycanonic acid is exhibited. |
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| Keywords: | titanocene dichloride titanocene carbohydrate cervical cancer liver cancer hepatic targeting |
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