| 阿奇霉素相关物的制备 |
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| 引用本文： | 刘聪,付艳杰,聂乙娇,姚国伟,孙立权,戴荣继.阿奇霉素相关物的制备[J].北京理工大学学报,2014,34(1):106-110. |
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| 作者姓名： | 刘聪 付艳杰 聂乙娇 姚国伟 孙立权 戴荣继 |
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| 作者单位： | 北京理工大学 生命学院, 北京 100081 |
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| 基金项目： | 国家“十一五”科技支撑项目（2008BA155B 04-2-1） |
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| 摘 要： | 为解决国内缺少阿奇霉素杂质对照品的现状，加强阿奇霉素的质量控制，通过化学合成或半制备液相色谱分离的方法制备了红霉素A 6，9-亚胺醚，红霉素A 9，11-亚胺醚，3-去克拉定糖阿奇霉素，3’-N-去甲基阿奇霉素，3’-N-去甲基-3’-N-对-乙酰胺基苯磺酰基阿奇霉素和阿奇霉素B 6种杂质的纯品. 经过核磁共振、质谱等手段确认各化合物结构正确；并从生产工艺出发详细分析了各杂质的来源和可行的控制方法.
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| 关 键 词： | 阿奇霉素 相关物 质量控制 阿奇霉素B 3-去克拉定糖阿奇霉素 3’-N-去甲基阿奇霉素 |
| 收稿时间： | 8/4/2012 12:00:00 AM |
Preparation of Azithromycin Related Substances |
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| LIU Cong,FU Yan-jie,NIE Yi-jiao,YAO Guo-wei,SUN Li-quan and DAI Rong-ji.Preparation of Azithromycin Related Substances[J].Journal of Beijing Institute of Technology(Natural Science Edition),2014,34(1):106-110. |
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| Authors: | LIU Cong FU Yan-jie NIE Yi-jiao YAO Guo-wei SUN Li-quan and DAI Rong-ji |
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| Institution: | School of Life Science, Beijing Institute of Technology, Beijing 100081, China |
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| Abstract: | Six compounds were made by chemical synthesis or semi-preparative HPLC separation for azithromycin to promote quality and impurity control. They are erythromycin A 6,9-imino ether, erythromycin A 9, 11-imino ether, 3'-N-demethyl azithromycin, 3'-N-4-(acetylamino)phenyl]sulphonyl]-3'-N-demethyl azithromycin, 3-decladinosylazithromycin and 12-dedeoxyazithromycin (azithromycin B), which were obtained through chemical synthesis or semi-preparative HPLC separation. Their structures are identified by MS, 1H NMR and 13C NMR. The source and control methods of these impurities are also presented to improve azithromycin production process. |
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