一种复合营养素制剂的毒理学研究

通过小鼠急性经口毒性试验、遗传毒性试验（Ames试验、小鼠骨髓细胞微核试验、小鼠精子畸形试验）和大鼠30 d喂养试验，对以番茄红素油树脂、葡萄籽提取物为主要原料制成的复合营养素制剂进行毒理学研究.结果表明，样品对小鼠的最大耐受剂量（MTD）大于20 000 mg/kg BW，急性经口毒性属无毒级；3项遗传毒性试验结果均为阴性；30 d喂养试验中，各剂量组大鼠生长良好，血液指标、组织学检查等均未见与样品有关的异常改变.在试验剂量下，该复合营养素制剂是安全的.

Toxicological Study on the Preparation of Compound Nutrients

Several tests were carried out to study the toxicology of the preparation of compound nutrients, including acute toxicity test in mice, genetic toxicity test (Ames test, mice bone marrow cell micronucleus test and mice sperm abnormality test), and 30 days feeding test in rats. The preparation of compound nutrients was made mainly of lycopene and grape seed extract. The results show that, the MTD of the tested are more than 20 000 mg/kg BW, acute toxicity is no toxicity; the three genetic toxicity tests are all negative; in 30 days feeding test, each dose group rats grows well, blood indexes and histological examination etc. are no abnormal changes related to the sample. It can be concluded that the preparation of compound nutrients is safe under the test dose.