| 蛋白质-核酸复合物中氢键和范德华力作用位点偏好性分析 |
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| 引用本文： | 吴建盛,晏善成,武灵芝,汤丽华.蛋白质-核酸复合物中氢键和范德华力作用位点偏好性分析[J].南京邮电大学学报(自然科学版),2011,31(4):138-144. |
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| 作者姓名： | 吴建盛 晏善成 武灵芝 汤丽华 |
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| 作者单位： | 1. 南京邮电大学地理与生物信息学院,江苏南京,210046
2. 南京邮电大学地理与生物信息学院,江苏南京210046;东南大学生物电子学国家重点实验室,生物科学与医学工程学院,江苏南京210096 |
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| 基金项目： | 南京邮电大学科研启动基金项目(NY209027)资助项目 |
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| 摘 要： | 对蛋白质-核酸复合物结构中氢键/范德华力作用位点氨基酸与核苷酸的偏好性(即相对使用频率)进行了统计分析.发现:(1)在蛋白质-DNA复合物结构中,范德华力作用对与氢键数量相当；而在蛋白质-RNA复合物结构中,范德华力作用对数量要远多于氢键；(2)复合物结构中氢键和范德华力作用位点上对氨基酸的偏好性差异显著；(3)氨基酸...
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| 关 键 词： | 蛋白质-核酸复合物 氢键 范德华力 偏好性 氨基酸极性 |
Analysis of Propensities at Hydrogen Bonding/Van der Waals Contacting Interfaces in Protein-nucleic Acid Complexes |
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| WU Jian-sheng,YAN Shan-cheng,WU Ling-zhi,TANG Li-hua.Analysis of Propensities at Hydrogen Bonding/Van der Waals Contacting Interfaces in Protein-nucleic Acid Complexes[J].Journal of Nanjing University of Posts and Telecommunications,2011,31(4):138-144. |
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| Authors: | WU Jian-sheng YAN Shan-cheng WU Ling-zhi TANG Li-hua |
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| Institution: | WU Jian-sheng1,YAN Shan-cheng1,WU Ling-zhi1,TANG Li-hua1,2(1.College of Geography and Biological Information,Nanjing University of Posts and Telecommunications,Nanjing 210046,China2.State Key Laboratory of Bioelectronics,School of Biological Science and Medical Engineering,Southeast University,Nanjing 210096,China) |
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| Abstract: | Statistical analysis is made of propensities of amino acids and nucleotides usage at protein-nucleic acid interfaces by hydrogen bonds or van der Waals contacts.The results have shown that:(1) For the number of van der Waals contacts,it is roughly the same as that of hydrogen bonds in the protein-DNA complex structures,but is far more than the latter in the protein-RNA complex structures.(2) In protein-nucleic acid complex structures,there are significant differences between the interaction propensities of ... |
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| Keywords: | protein-nucleic acid complex hydrogen bonds van der Waals contacts binding propensity polarity of amino acids |
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