| 联苯/环糊精包合物的药物释放研究 |
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| 引用本文： | 余海斌,徐定宇,鲍续进.联苯/环糊精包合物的药物释放研究[J].北京化工大学学报(自然科学版),1992(1). |
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| 作者姓名： | 余海斌 徐定宇 鲍续进 |
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| 作者单位： | 北京化工学院高分子系，北京化工学院高分子系，北京化工学院高分子系 南开大学高分子化学研究所 |
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| 摘 要： | 研究了联苯/环糊精(BP/CD)包合物的联苯释放过程。通过比较联苯和BP/CD的热重曲线,发现BP/CD对联苯的稳定作用,对BP/CD及BP/CD填充聚乙烯膜的联苯释放过程进行比较,发现在较薄的填充薄膜中,BP的释放过程是以BP从CD中的解离为控制步骤。此外,还推导了BP/CD的释放反应动力学方程,并计算了活化能。
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| 关 键 词： | 联苯 环糊精 包合物 药物 释放 |
Study on Releasc Drug of Biphenyl in Cyclodextrin (BP/CD) Inclusion Compound |
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| Yu Haibin,Xu Dingyu,Bao Xujing.Study on Releasc Drug of Biphenyl in Cyclodextrin (BP/CD) Inclusion Compound[J].Journal of Beijing University of Chemical Technology,1992(1). |
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| Authors: | Yu Haibin Xu Dingyu Bao Xujing |
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| Institution: | Yu Haibin;Xu Dingyu;Bao Xujing Department of polymer science |
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| Abstract: | This paper deals with the releasing process of BP in BP / CD inclusion com-pound.The influence of BP / CD on the stability of BP can be discovered by comparing thedifference of thermogravimetric curve of BP and BP / CD. The releasing process of BP wascontrolled by the dissociation of BP from CD in thinner filled films on comparing the re-leasing process of BP / CD and BP / CD filled in PE films. The releasing reaction kineticsequation of BP / CD was derived and the activation energy was calculated. |
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| Keywords: | biphenyl cyclodextrin inclusion drug release |
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