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溴甲酚绿法测定盐酸美金刚缓释胶囊的释放度
引用本文:李青原,赵会英,蒲玉琦.溴甲酚绿法测定盐酸美金刚缓释胶囊的释放度[J].北京化工大学学报(自然科学版),2015,42(4):73.
作者姓名:李青原  赵会英  蒲玉琦
作者单位:北京化工大学生命科学与技术学院,北京,100029;北京化工大学生命科学与技术学院,北京,100029;北京化工大学生命科学与技术学院,北京,100029
摘    要:建立了一种简便灵敏的用于测定盐酸美金刚缓释胶囊释放度的分析方法。采用溶剂萃取酸性染料比色法来测定盐酸美金刚缓释胶囊的释放度,染色剂选用溴甲酚绿(BCG),萃取剂为氯仿,通过改变水相p H、BCG试液用量、反应时间等条件对比色法的测定条件进行优化。结果显示,当水相p H=4.0、溴甲酚绿试液用量为4 m L时,本方法在0.3~12μg/m L质量浓度范围内具有较高的灵敏度和重复性,标准曲线为A=0.05347ρ+0.09001,r=0.9991(n=6);盐酸美金刚平均回收率为100.13%,相对标准偏差为1.86%(n=9)。

关 键 词:盐酸美金刚缓释胶囊  酸性染料比色法  溴甲酚绿  释放度
收稿时间:2014-12-03

A bromocresol green spectrophotometric method for determining the release of memantine hydrochloride sustained release capsules
LI QingYuan,ZHAO HuiYing,PU YuQi
.A bromocresol green spectrophotometric method for determining the release of memantine hydrochloride sustained release capsules[J].Journal of Beijing University of Chemical Technology,2015,42(4):73.
Authors:LI QingYuan  ZHAO HuiYing  PU YuQi
Institution:College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China
Abstract:The aim of this study is to establish a simple and sensitive detection method for memantine hydrochloride from sustained release capsules.Bromocresol green is used as the coloring agent and chloroform as the extracting agent. The factors influencing this acid dye colorimetric method such as the aqueous pH,the amount of bromocresol green and the reaction time,were investigated. The results show that,when the volume of chloroform is fixed at 5mL,the aqueous pH at 4,and the amount of bromocresol green set at 4mL,the bromocresol green spectrophotometric method has a sufficiently high sensitivity to determine the small amount of released memantine hydrochloride. There is a good correlation (A=0.05347ρ+0.09001) between the absorbance and the concentration within the range 0.3-12μg/mL (r=0.9991,n=6).The average recovery was 100.13% with a relative standard deviation of 1.86% (n=9).
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