| 聚羟基丁酸酯/氟磷灰石电纺丝膜的体外降解 |
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| 引用本文： | 赵冬梅,徐日炜,余鼎声,陈子扬.聚羟基丁酸酯/氟磷灰石电纺丝膜的体外降解[J].北京化工大学学报(自然科学版),2008,35(3):43-48. |
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| 作者姓名： | 赵冬梅 徐日炜 余鼎声 陈子扬 |
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| 作者单位： | 北京化工大学新型高分子制备与加工北京市重点实验室， 北京 100029 |
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| 摘 要： | 首次研究了氟含量不同的聚羟基丁酸酯/氟磷灰石电纺丝膜(PHB/FHAP)的体外降解行为，考察了PHB和PHB/FHAP电纺丝膜的失重率、降解液浑浊度及表面微观形貌，结果表明FHAP的加入增大了PHB电纺丝膜的降解速率。随着氟含量的增加，PHB/FHAP降解速率减小。在降解介质磷酸缓冲溶液（PBS）中，PHB和PHB/FHAP电纺丝膜都出现了羟基磷灰石（HAP）前驱体，表明该材料具有较好的生物相容性，这对其在骨组织工程上的应用具有重要意义。
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| 关 键 词： | 聚羟基丁酸酯 氟磷灰石 电纺丝膜 体外降解 组织工程 聚羟基丁酸酯 氟磷灰石 电纺丝膜 体外降解 组织工程 |
| 收稿时间： | 2007-11-20 |
In vitro degradation behavior of electrospun poly (3-hydroxybutyrate-co-4-hydroxybutyrate) / fluoroapatite (PHB/FHAP) films |
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| ZHAO DongMei,XU RiWei,YU DingSheng,CHEN ZiYang.In vitro degradation behavior of electrospun poly (3-hydroxybutyrate-co-4-hydroxybutyrate) / fluoroapatite (PHB/FHAP) films[J].Journal of Beijing University of Chemical Technology,2008,35(3):43-48. |
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| Authors: | ZHAO DongMei XU RiWei YU DingSheng CHEN ZiYang |
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| Institution: | The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | The in vitro degradation behavior of electrospun PHB/FHAP films with different fluorine contents is reported for the first time.The weight loss,turbidity of the solution after degradation and morphology of the PHB/FHAP film were investigated.The results showed that the degradation rates of PHB/FHAP films are higher than that of a PHB film.The degradation rate of the PHB/FHAP films decreased with increasing fluorine content.The precursor to hydroxyapatite was observed on PHB/FHAP and PHB films after degradation in phosphate buffer solutions(PBS),showing the good biocompatibility of both films.The results reported here provide an important guide to developing applications of the films in bone tissue engineering. |
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| Keywords: | poly(3-hydroxybutyrate-co-4-hydroxybutyrate) fluoroapatite electrospinning in vitro degradation tissue engineering scaffold |
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