| HPLC法监测DL-丝氨酸的合成研究 |
| |
| 引用本文： | 傅莉,刘信洪,徐春艳,薛传薪.HPLC法监测DL-丝氨酸的合成研究[J].北京化工大学学报(自然科学版),2003,30(4):105-108. |
| |
| 作者姓名： | 傅莉 刘信洪 徐春艳 薛传薪 |
| |
| 作者单位： | 北京化工大学理学院,北京,100029 |
| |
| 摘 要： | 采用HPLC方法，以OPA为柱前衍生化试剂，对常压下甘氨酸铜法合成DL-丝氨酸的过程进行了监控，通过改变加料方式及调节pH值，提高了丝氨酸的含量，得出了常压下丝氨酸的最佳合成条件为：n铜离子∶n甘氨酸∶n甲醛=1∶278∶973，pH =8.5～9.5 ,反应时间1.5h，丝氨酸最高质量浓度为18.86 g/L。
|
| 关 键 词： | 甘氨酸 丝氨酸 HPLC α-羟甲基丝氨酸 甘氨酸 丝氨酸 HPLC α-羟甲基丝氨酸 |
| 修稿时间： | 2002年11月5日 |
Monitoring a process for preparing DL-serine by HPLC |
| |
| FU Li LIU Xin-hong XU Chun-yan XUE Chuan-xin.Monitoring a process for preparing DL-serine by HPLC[J].Journal of Beijing University of Chemical Technology,2003,30(4):105-108. |
| |
| Authors: | FU Li LIU Xin-hong XU Chun-yan XUE Chuan-xin |
| |
| Institution: | College of Science; Beijing University of Chemical Technology; Beijing; China |
| |
| Abstract: | DL-serine was, from glycine and formaldehyde, prepared catalytically in an alkali medium at an atmosphere and the reaction mixture was analyzed by HPLC quantitatively. The reaction conditions, such as charging mode,molar ratio,pH value and so on, were examined. The optimal conditions are experimentally selected as follows: ncopperion ∶ nglycine ∶ nformaldehyde =1∶278∶973, pH=8.5～9.5, in the way of adding formaldehyde with an alkali medium. The reaction time is 1.5h and the best yield of serine under these condition is about 18.86L/g. |
| |
| Keywords: | glycine serine HPLC α-hydroxymethylserine |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《北京化工大学学报(自然科学版)》浏览原始摘要信息 |
| 点击此处可从《北京化工大学学报(自然科学版)》下载免费的PDF全文 |
