| 洛伐他汀聚乳酸缓释微球的制备及其体外释药 |
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| 引用本文： | 张敏,张丽叶.洛伐他汀聚乳酸缓释微球的制备及其体外释药[J].北京化工大学学报(自然科学版),2011,38(2):94-98. |
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| 作者姓名： | 张敏 张丽叶 |
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| 作者单位： | 北京化工大学,生命科学与技术学院,北京,100029;北京化工大学,生命科学与技术学院,北京,100029 |
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| 摘 要： | 采用油/水型乳化溶剂挥发法制备了洛伐他汀聚乳酸缓释微球，通过正交试验筛选最优制备工艺；考察了微球的粒径，形态，及载药量、包封率等特征，采用透析法进行微球体外释药研究。结果表明由最佳工艺制备的洛伐他汀聚乳酸微球形态圆整，粒径分布较为均匀。分子量5万聚乳酸制备的微球，载药量32.28%，包封率81.81%，平均粒径65.8μm ；分子量3万聚乳酸制备的微球，载药量27.66%,包封率60.84%，平均粒径63.3μm。二者在10d内体外累积释放率分别为34.81%和40.96%，释药动力学符合Higuchi方程。
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| 关 键 词： | 洛伐他汀 聚乳酸微球 体外释放 |
| 收稿时间： | 2010-09-27 |
Preparation and in vitro release properties of lovastatin-polylactic acid microspheres |
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| ZHANG Min ZHANG LiYe.Preparation and in vitro release properties of lovastatin-polylactic acid microspheres[J].Journal of Beijing University of Chemical Technology,2011,38(2):94-98. |
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| Authors: | ZHANG Min ZHANG LiYe |
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| Institution: | College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, China |
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| Abstract: | Lovastatin-polylactic acid(PLA) microspheres have been prepared using a solvent evaporation-extraction method.The synthesis process was optimized using orthogonal tests and the factors that influence the process were analyzed.The surface morphology and average diameter of the microspheres were characterized by scanning electron microscopy,and the drug-loading ratio and encapsulation ratio were calculated.The dialysis method was used to study the drug release properties.Microspheres prepared by the optimized... |
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| Keywords: | lovastatin polylactic acid microspheres drug release in vitro |
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