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聚乳酸及其共聚物的制备和降解性能
引用本文:马晓妍,石淑先,夏宇正,焦书科,李效玉.聚乳酸及其共聚物的制备和降解性能[J].北京化工大学学报(自然科学版),2004,31(1):51-56.
作者姓名:马晓妍  石淑先  夏宇正  焦书科  李效玉
作者单位:北京化工大学新型高分子材料的制备与加工北京市重点实验室,北京,100029
基金项目:北京化工大学校科研和教改项目
摘    要:以D,L-丙交酯和聚乙二醇为原料,在催化剂辛酸亚锡作用下常压氮气保护制备了聚乳酸及其聚乙二醇改性聚乳酸.考察了聚合温度、辛酸亚锡用量对聚乳酸相对分子质量的影响及聚合物在不同降解介质中和不同相对分子质量聚合物的降解规律,并用IR,1H-NMR,GPC对聚乳酸及其共聚物进行了表征.结果表明,当单体和辛酸亚锡的摩尔比为5 000、聚合温度在160 ℃时,常压聚合5 h即可得到适合作药物控释载体且黏均相对分子质量为6.3×104的聚乳酸;聚乳酸在去离子水、0.01 mol/L盐酸溶液、pH=7.4磷酸盐缓冲液、0.01 mol/L氢氧化钠溶液4种降解介质中,在碱液中的降解速率最快;相对分子质量较小的聚乳酸降解较快,且聚乙二醇改性的聚乳酸比聚乳酸降解快.

关 键 词:丙交酯  聚乳酸  聚乙二醇改性聚乳酸  制备  降解  丙交酯    聚乳酸    聚乙二醇改性聚乳酸    制备    降解
收稿时间:2003-09-11
修稿时间:2003年9月11日

Preparation and degradation of polylactide and its copolymer
Ma Xiao-yan,Shi Shu-Xian,Xia Yu-zheng,Jiao Shu-ke,Li Xiao-yu.Preparation and degradation of polylactide and its copolymer[J].Journal of Beijing University of Chemical Technology,2004,31(1):51-56.
Authors:Ma Xiao-yan  Shi Shu-Xian  Xia Yu-zheng  Jiao Shu-ke  Li Xiao-yu
Institution:The Key Laboratory of Beijing City on Preparation and Processing of Novel Polymer Materials, Beijing University of Chemical Technology, Beijing, China
Abstract:Poly(D, L-lactide)(PLA) and poly(D, L-lactide)-poly(ethylene glycol) (PEG, Mn= 2000) were synthesized from D, L-lactide(LA) and PEG with stannous octoate as the catalyst in the presence of N2 under the normal pressure. The effect of temperature of polymerization and catalyst content on the relative molecular weights of PLA, and the regularity of degradation at different media and for different molecular weights of polymers were discussed in detail. The polylactide and its copolymer were characterized by infared spectroscopy(IR), nuclear magnetic resonance(1H-NMR) and gel permeation chromatography(GPC). The media used for testing of degradation were distilled water, 0.01mol/L HCl solution, pH=7.4 phosphate buffer solution and 0.01mol/L NaOH solution. The results show that the Mv of PLA which was polymerized in 5h, at the lactide/PEG mole feed ratio of 5000, at 160℃ under the nomal pressure is 6.3×104 and PLA is degraded more rapidly in NaOH solution. the lower relative molecular weight of PLA is degraded more rapidly in the same medium. Compared with PLA, degradetion of the copolymer is more rapidly.
Keywords:lactide  polylactide  polyethylene glycol modified polylactide  preparation  degradation
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