| N-(3,6-二甲基-4-苯甲酰基)苯基-2-羟基-3,5,6-三氯苯磺酰胺化合物的解偶联活性研究 |
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| 引用本文： | 王晓晶,牛雪平,赵军,石玉,新民.N-(3,6-二甲基-4-苯甲酰基)苯基-2-羟基-3,5,6-三氯苯磺酰胺化合物的解偶联活性研究[J].内蒙古大学学报(自然科学版),2000,31(1). |
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| 作者姓名： | 王晓晶 牛雪平 赵军 石玉 新民 |
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| 作者单位： | 内蒙古大学化学系!内蒙古呼和浩特010021 |
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| 摘 要： | 研究了治疗牛、羊等家畜肝片吸虫病药物Ｎ－（３，６－二甲基－４－苯甲酰基）苯基－２－羟基－３，５，６－三氯苯磺酰胺化合物的杀虫活性．采用氧电极法、测线粒体呼吸过程中磷的变化以及测ＡＴＰ酶活性等方法研究其对线粒体氧化磷酸化反应的解偶联活性．结果表明：标题药物化合物是较好的解偶联剂，其解偶联活性与已商品化的抗肝片吸虫药物化合物Ｎ－（２，４，５－三氯）苯基－２－羟基－（３，５，６－三氯）苯磺酰胺相当或略高．
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| 关 键 词： | N-(3 6-二甲基-4-苯甲酰基)苯基-2-羟基-3 5 6-三氯苯磺酰胺 杀虫活性 肝片吸虫 解偶联 |
The Study on the Fasciolicidal Activities against Parasite Fasciola Hepatica for the Drug Compound HBSN CO_2 |
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| WANG Xiao jing,NIU Xue ping,ZHAO Jun,SHI Yu,XIN Min.The Study on the Fasciolicidal Activities against Parasite Fasciola Hepatica for the Drug Compound HBSN CO_2[J].Acta Scientiarum Naturalium Universitatis Neimongol,2000,31(1). |
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| Authors: | WANG Xiao jing NIU Xue ping ZHAO Jun SHI Yu XIN Min |
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| Abstract: | The uncoupling activities of HBSN,HBSN CO1 and HBSN CO2 were measured in rat liver mitochondria.Uncoupling activities were determined by measuring stimulation of state 4 respiration,the increase of Pi in reaction medium and the effect of drugs on the mitochondrial ATP ase .The results showed that :the title drug compound was a good uncoupler of the oxidative phosphorylation and comparing with the commercial drug N (2,4,5 trichloro)phenyl 2 hydroxyl 3,5,6 trichlorobenzenesulfonamilide (HBSN) against parasite fasciola hepatica,its uncoupling activity was a little higher or quivalent to HBSN. |
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| Keywords: | N-(3 6 bimethyl-4-benzoyl- )phenyl-2-hydroxyl- 3 5 6 trichloro benzensulfonamilide fasciolicidal activity parasite fasciola hepatica uncoupling |
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