| 大肠杆菌SD序列与基因表达水平的关系 |
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| 引用本文： | 李宏,达赖.大肠杆菌SD序列与基因表达水平的关系[J].内蒙古大学学报(自然科学版),1998,29(2):172-176. |
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| 作者姓名： | 李宏 达赖 |
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| 作者单位： | [1]内蒙古大学理论物理和理论生物学研究室 [2]内蒙古大学生命科学院生物系生化教研室 |
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| 基金项目： | 国家自然科学基金,内蒙教育厅基金 |
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| 摘 要： | 依据基因表达水平的理论预测方法从１３７３个大肠杆菌基因中选出了７３个甚高表达基因和１００个甚低表达基因，研究了这两类基因编码区起始密码子ＡＴＧ前－１到－２１位点（包含ＳＤ序列）的碱基构成与基因表达水平的关系。结果表明，ＳＤ序列中的富嘌呤区（约在－７到－１２位点）Ｇ和Ｔ的概率分布曲线中心到ＡＴＧ的距离（记为ＬＨ）与基因表达水平有明显的关系。甚高表达基因ＬＨ约为１０，甚低表达基因的ＬＨ约为８，另外在－
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| 关 键 词： | SD区域 基因表达水平 大肠杆菌 |
The Relation between Shine-Dalgarno Region and Gene Expression Level in E.coli |
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| Li Hong ,Yang Tiqiang ,Da Lai ,Luo Liaofu.The Relation between Shine-Dalgarno Region and Gene Expression Level in E.coli[J].Acta Scientiarum Naturalium Universitatis Neimongol,1998,29(2):172-176. |
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| Authors: | Li Hong Yang Tiqiang Da Lai Luo Liaofu |
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| Institution: | Li Hong 1,Yang Tiqiang 1,Da Lai 2,Luo Liaofu 1 |
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| Abstract: | Using the self consistent information cluster method,we select 73 very high expressed genes and 100 very low expressed genes from 1 373 E.coli genes and analyze their base distribution of -1 to -21 sites before ATG codon.We find that the base distribution at -1 to -21 sites (including SD region) are correlated to the gene expresseion levels,the distance from ATG to the center of SD region (Shine-Dalgarno region) which corresponding to the position of maximum P (G) and the position of minimum P (T) is increased from 8 bases for very low expressed genes to 10 bases for very high expressed genes. In addition,for very high expressed genes,the probability of base T and base C in site -1 are different from very low expressed genes. |
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| Keywords: | SD region gene expression level E coli |
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