| D-青霉胺的膳食剂量对大鼠体内铜锌代谢水平的影响 |
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| 引用本文： | 徐虹,青山赖孝,宋焕禄.D-青霉胺的膳食剂量对大鼠体内铜锌代谢水平的影响[J].北京工商大学学报(自然科学版),2010,28(4):26-30. |
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| 作者姓名： | 徐虹 青山赖孝 宋焕禄 |
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| 作者单位： | 1. 北京工商大学,化学与环境工程学院/食品添加剂与配料北京高校工程研究中心,北京,100048
2. 日本名古屋文理大学,健康生活学部,日本爱知县,492-8520 |
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| 摘 要： | 研究实验分别将0.1%,0.2%,0.3%,0.4%,0.5%和1.0%的口服D-青霉胺混合在膳食成分中让实验大鼠通过摄食自然摄取,旨在寻求一种更为简便和人道的治疗途径,并探讨其有效移除大鼠体内铜元素的最适膳食剂量.实验结果发现0.3%和0.4%D-青霉膳食可以显著地移除大鼠肝脏和血清中的铜元素,而且未发现明显的毒副作用,因此0.3%~0.4%被认为是D-青霉胺最适的膳食剂量.研究结果还表明铜和锌在大鼠肝脏内的代谢途径并不一致.
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| 关 键 词： | D-青霉胺 膳食剂量 大鼠 铜 锌 |
EFFECT OF DIETARY D-PENICILLAMINE DOSE FACTOR ON \=METABOLISM OF COPPER AND ZINC IN RATS |
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| XU Hong,AOYAMA Yoritaka and SONG Huan-lu.EFFECT OF DIETARY D-PENICILLAMINE DOSE FACTOR ON \=METABOLISM OF COPPER AND ZINC IN RATS[J].Journal of Beijing Technology and Business University:Natural Science Edition,2010,28(4):26-30. |
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| Authors: | XU Hong AOYAMA Yoritaka and SONG Huan-lu |
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| Institution: | XU Hong1,AOYAMA Yoritaka2,SONG Huan-lu1(1.College of Chemical and Environmental Engineering/Beijing Technology and Business University,Beijing Higher Institution Engineering Research Center of Food Additives and Engredients,Beijing 100048,China,2.School of Health and Human Life,Nagoya Bunri University,Inazawa 492-8520,Japan) |
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| Abstract: | To establish an easier and more humane treatment way,experimental rats were respectively fed 0.1%,0.2%,0.3%,0.4%,0.5% and 1.0% of D-penicillamine mixing with dietary compositions,and the proper dietary D-penicillamine dose was discussed.The results indicated that the doses of 0.3% and 0.4%of D-penicillamine effectively decreased the copper content in liver and serum of rats through promoting the urinary output of copper without side-effects.Therefore,0.3%~0.4% was considered as the best dietary D-penicillam... |
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| Keywords: | D-penicillamine dietary dose rats copper zinc |
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