蛇六谷葡甘聚糖抗肿瘤研究

以蛇六谷为研究对象,利用自制蛇六谷葡甘聚糖降解产物,通过实验探讨蛇六谷葡甘聚糖短链分子抗肿瘤作用.分析结果表明,蛇六谷葡甘聚糖短链分子能够抑制He La细胞的生长,但总体抑制效果不明显;不同剂量蛇六谷葡甘聚糖短链分子对S180荷瘤小鼠肿瘤的增长都有抑制作用,且随着剂量的增大,抑制效果越明显.初步研究结果表明,蛇六谷葡甘聚糖短链分子有抗肿瘤活性.利用X射线衍射、红外光谱、拉曼光谱和圆二色谱对蛇六谷进行结构分析,结果证明蛇六谷的抗肿瘤功效可能与其含有的葡甘聚糖有关.

Study on Antitumor Activity of Konjac Glucomannan from Rhizoma Amorphophalli

The antitumor activity of konjac glucomannan (KGM) short chain polymer of rhizoma amorphophalli was discussed in this study. The results showed that KGM short chain polymer of rhizoma amorphophalli inhibited the growth of HeLa cells with the unobvious effect. KGM short chain polymer of rhizoma amorphophalli inhibited the tumor growth of S180 tumor bearing mice under different doses. Moreover, the antitumor activity increased with the increasing doses. The molecular structure of rhizoma amorphophalli was analyzed by X-ray diffraction, infrared spectroscopy, Raman spectroscopy, and circular dichroism. The results showed that the antitumor activity of rhizoma amorphophalli was related to the KGM content.