抗独特型抗体在食用农产品危害物监控中的应用研究

食用农产品质量安全危害物来源广、种类多,从产地环境到农业投入品再到收储运环节,生物、化学污染物危害风险几乎伴随整个产供链。对危害物的高效监测,以及探索更为安全的危害物(特别是高毒投入品)替代功能效应物是食用农产品质量安全监控可持续发展的必然要求。基于“免疫网络学说”的抗独特型抗体,因具有模拟抗原表位构象乃至生物活性的特性,已被证实可以用于免疫原功能效应物创制,这为食用农产品质量安全危害物检测或功能替代材料研发提供了新思路。系统梳理了食用农产品产供过程中可能涉及的危害物及其安全风险；全面整理并介绍了抗独特型抗体技术及其在食用农产品质量安全危害物监控中的应用状况；结合作者及所在团队近年科研成果,探讨了抗独特型抗体在食用农产品质量安全危害物监控中的应用前景、存在问题以及拟解决对策。

Study on Anti-Idiotype Antibodies Used for Monitoring Hazards in Edible Agricultural Products

The hazards which affect the quality and safety in edible agricultural products are widely sourced and varied. The hazard risks of biological and chemical pollutants almost accompany the entire supply chains in edible agricultural products, from production environment and agricultural inputs to the harvest, storage and transportation links. It is an inevitable requirement for the sustainable development to efficiently monitor the hazardous materials and research its functional effector for edible agricultural products. The immune network theory-based anti-idiotype antibodies have been proved to be useful for antigenic effector preparation because the characterizing of simulate conformation and even biological activity of antigenic epitope, which provided a new idea of monitoring the hazards of edible agricultural products or functional alternative materials. In this study, the hazards and safety risks which may involve in the process of production and supply of edible agricultural products have been systematically sorted out.Meanwhile, anti-idiotype antibodies technology and the application status in monitoring hazards of edible agricultural products have been comprehensively introduced and collated.Finally, we have studied the application prospects, existing problems and counter measures of anti-idiotype antibodies for monitoring hazards in edible agricultural products.