基于海洋生物多聚物的功能因子递送系统

基于海洋多聚物的纳米材料是一种新型的功能因子负载体系,临床应用中药物与功能因子的递送方式主要有3种,分别是口服、经皮和注射,但由于体感差、药物递送量低、副作用和有效成分活性丧失等诸多问题的困扰,人们更加希望选择既能提高医疗效果和健康水准,又能满足良好舒适性的传输递送方式。研究发现基于海洋多聚物的纳米材料与传统口服递送体系的系统结合可以实现抗癌药物、营养物质、益生菌、疫苗等功能成分的高效递送,大大提高了上述成分的整体生物利用度。通过阐述纳米载体的制备、功能因子的负载及其吸收机制为基于海洋多聚物功能因子递送体系的发展提供参考和借鉴。

Marine Biopolymers-Based Delivery System for Functional Ingredients

Nanocomposites based on marine polymers are a new type of functional ingredients loading system. The most widely used three delivery methods of drug and functional ingredients in clinical practice were oral, transdermal and injection. However, due to many problems such as poor body sensation, low drug delivery, side effects and loss of active ingredient activity, people gradually chose a delivery method that could improve medical care, health and meet good comfort. The combination of oral and nanocomposites based on marine polymers carriers enabled efficient delivery of functional components such as anticancer drugs, nutrients, probiotics, vaccines, etc, greatly improving the overall bioavailability of the above components. This paper might provide references for the development of marine multi-functional ingredients delivery systems via describing the preparation of nanocarriers, the loading of functional ingredients and their absorption mechanisms.