模式生物斑马鱼在心血管疾病研究中的应用

斑马鱼近年来被广泛地应用于医学研究中。斑马鱼个体小、养殖费用低廉、身体透明，及易于基因操作等优势，使其成为一种理想的模式生物。笔者综述了模式生物斑马鱼在心血管疾病研究中的应用。首先介绍了斑马鱼的心血管发育、心血管影像、相关遗传学技术及斑马鱼作为模式生物在心血管疾病研究中的优势与不足；然后通过总结既往的研究，重点阐述了斑马鱼在动脉粥样硬化、心律失常、心肌病、先天性心脏病、心力衰竭、心脏再生、炎症、动脉生成、血栓及心血管药物筛选等领域的应用进展。

Zebrafish as a model to study cardiovascular diseases

Over the last few years, the zebrafish has entered the field of medical research. The zebrafish possesses a host of advantages that made it as an excellent model organism. These advantages include small size and cost, optical clarity and ease of genetic manipulation and transgenesis. In this review, we focus on the use of the zebrafish for the research of cardiovascular diseases. Firstly, we introduce the cardiovascular development, cardiovascular imaging, and genetic techniques of the zebrafish. Secondly, we analyze the advantages and disadvantages of the zebrafish in cardiovascular research. Finally, we summarize previous studies with the use of this organism to model such diseases and processes as atherosclerosis, arrhythmia, cardiomyopathy, congenital heart diseases, heart failure, cardiac regeneration, inflammation, collateral vessel development, thrombosis, and novel drug screening.