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Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies |
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| Authors: | Service Susan DeYoung Joseph Karayiorgou Maria Roos J Louw Pretorious Herman Bedoya Gabriel Ospina Jorge Ruiz-Linares Andres Macedo António Palha Joana Almeida Heutink Peter Aulchenko Yurii Oostra Ben van Duijn Cornelia Jarvelin Marjo-Riitta Varilo Teppo Peddle Lynette Rahman Proton Piras Giovanna Monne Maria Murray Sarah Galver Luana Peltonen Leena Sabatti Chiara Collins Andrew Freimer Nelson |
| Institution: | Center for Neurobehavioral Genetics, University of California, Los Angeles, California 90095, USA. |
| Abstract: | The genome-wide distribution of linkage disequilibrium (LD) determines the strategy for selecting markers for association studies, but it varies between populations. We assayed LD in large samples (200 individuals) from each of 11 well-described population isolates and an outbred European-derived sample, using SNP markers spaced across chromosome 22. Most isolates show substantially higher levels of LD than the outbred sample and many fewer regions of very low LD (termed 'holes'). Young isolates known to have had relatively few founders show particularly extensive LD with very few holes; these populations offer substantial advantages for genome-wide association mapping. |
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