Chromatin-remodeling complex specificity and embryonic vascular development |
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Authors: | Carol D. Curtis Reema B. Davis Kyle G. Ingram Courtney T. Griffin |
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Affiliation: | 1. Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK, 73104, USA 2. Department of Cell Biology, University of Oklahoma Health Sciences Center, PO Box 26901, Oklahoma City, OK, 73190, USA
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Abstract: | Vascular development is a dynamic process that relies on the coordinated expression of numerous genes, but the factors that regulate gene expression during blood vessel development are not well defined. ATP-dependent chromatin-remodeling complexes are gaining attention for their specific temporal and spatial effects on gene expression during vascular development. Genetic mutations in chromatin-remodeling complex subunits are revealing roles for the complexes in vascular signaling pathways at discrete developmental time points. Phenotypic analysis of these models at various stages of vascular development will continue to expand our understanding of how chromatin remodeling impacts new blood vessel growth. Such research could also provide novel therapeutic targets for the treatment of vascular pathologies. |
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