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Evidence for an unusual multifunctional protoreceptor in hormone action
Authors:M K Agarwal  J Paillard  M Philippe
Institution:(1) INSERM and CNRS, F-75005 Paris, (France);(2) Present address: 15, rue de l'Ecole de Médecine, F-75270 Paris Cedex 06, France
Abstract:Summary Contrary to the techniques of mere association, column chromatography has revealed a lsquoprotoreceptorrsquo that accepts aldosterone agonists and antagonists only in the physiological target, the kidney, and is absent in non-targets, liver and serum; it is furthermore different from the aldosterone specific receptor in renal cytosol.Supported in part by grants from the CNRS AI 03 1917 and UER Broussais Hôtel Dieu.
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