| 硫氢酸钠催化合成氯乙酸异丙酯 |
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| 引用本文： | 张杰. 硫氢酸钠催化合成氯乙酸异丙酯[J]. 科学技术与工程, 2011, 11(11): 2519-2522 |
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| 作者姓名： | 张杰 |
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| 作者单位： | 渤海大学科技实验中心辽宁省功能化合物合成与应用重点实验室,渤海大学化学化工与食品安全学院,锦州,121013 |
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| 基金项目： | 无机合成与制备化学国家重点实验室(吉林大学)开放课题(2011—29); 辽宁省高等学校优秀人才支持计划(2009R02); 辽宁省人事厅“百千万人才工程”项目(2008921042); 辽宁省教育厅省级工程技术研究中心建设计划(2009402007)资助 |
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| 摘 要： | 以硫酸氢钠作为催化剂合成氯乙酸异丙酯,研究了醇酸摩尔比、催化剂种类、催化剂用量、带水剂种类以及带水剂用量对合成氯乙酸异丙酯的酯化反应的影响.在醇酸摩尔比1.2/1、催化剂用量1.0%(以酸的摩尔数计量)、反应时间2.5 h、反应温度为回流温度以及10 mL环已烷作为带水剂的反应条件下,酯化率可达97.1%.
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| 关 键 词： | 氯乙酸异丙酯 催化酯化 催化剂 带水剂 |
| 收稿时间： | 2010-12-29 |
| 修稿时间： | 2010-12-29 |
Synthesis of isopropyl chloroacetate catalyzed by sodium bisulfate |
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| zhangjie. Synthesis of isopropyl chloroacetate catalyzed by sodium bisulfate[J]. Science Technology and Engineering, 2011, 11(11): 2519-2522 |
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| Authors: | zhangjie |
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| Affiliation: | ZHANG Jie,XU Jia-sheng,QIAN Jian-hua(Center of Science and Technology Experiment,Liaoning Province Key Laboratory for Synthesis and Application of Functional Compounds,College of Chemistry,Chemical Engineering and Food Safety,Bohai University,Jinzhou 121013,P.R.China) |
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| Abstract: | Isopropl chloroacetate was synthesized by esterification of chloroacetic acid with isopropanol using sodium bisulfate as catalyst. Various factors that affected the esterification have been investigated. Under the condition of 1.2/1 molar ratio of isopropanol to chloroacetic acid, 1.0% catalyst (molar percent of chloroacetic acid), 2.5 h reaction time, 10 mL cyclohexane as water-carrying agent and reflux temperature, the yield of isopropyl chloroacetate reaches 97.1%. |
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| Keywords: | isopropyl chloroacetate catalytic esterification catalyst water-carrying agent |
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